Mitomycin C as adjunct therapy in correcting punctal stenosis.

Purpose: To assess the efficacy of intraoperative mitomycin C in improving the success rate of the posterior punctectomy procedure.

Methods: The charts of all patients who underwent posterior punctectomy between the years 1997 and 2000 were reviewed. The procedure was done without mitomycin C (n = 26 eyes, group A) until the end of 1998 and with mitomycin C (n = 25 eyes, group B) starting in 1999. The Kaplan-Meier curve was used for statistical evaluation.

Results: In group A, 5 of 26 (19.2%) eyes had complete anatomic obstruction and scarring of their puncta after surgery, compared with 0 of 25 (0.0%) eyes in group B. The difference was statistically significant (P<0.02). No significant complications were observed.

Conclusions: Mitomycin C appears to be a safe and effective adjunct therapy in correcting punctal stenosis.