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Agonodepsides a and B: two new depsides from a filamentous fungus F7524. | LitMetric
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Agonodepsides a and B: two new depsides from a filamentous fungus F7524.

Shugeng Cao Alex S Y Lee Yicun Huang Horst Flotow Siewbee Ng Mark S Butler Antony D Buss

J Nat Prod

Centre for Natural Product Research, Institute of Molecular and Cell Biology, 59A Science Park Drive, The Fleming, Singapore Science Park 118240, Singapore.

Published: July 2002

Two new compounds, agonodepsides A (1) and B (2), were isolated from a nonsporulating filamentous fungus, F7524. The compounds were purified via reversed-phase chromatography and their structures determined by spectroscopic methods. Agonodepside A (1) was found to inhibit the mycobacterial InhA enzyme with an IC50 value of 75 microM, while 2 was inactive at 100 microM.

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http://dx.doi.org/10.1021/np010626iDOI Listing

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