AI Article Synopsis
- Two new a-glucosidase inhibitors, CKD-711 and CKD-711a, were isolated from Streptomyces sp. CK-4416 during fermentation.
- CKD-711 has a molecular formula of C25H43NO20, while CKD-711a has a larger molecular formula of C37H63NO30, indicating it contains two additional glucose units.
- The chemical structures of both compounds were thoroughly characterized using high-resolution two-dimensional NMR methods.
Article Abstract
We have isolated two novel a-glucosidase inhibitors, O-[4-deoxy-4-(2,3-epoxy-3-hydroxymethyl-4,5,6-trihydroxycyclohexane-1-yl-amino)-alpha-D-glucopyranosyl]-(1-->4)-O-alpha-D-glucopyranosyl-(1-->4)-alpha-D-glucopyranose (named CKD-711) and its hexameric analog CKD-711a, from the fermentation broth of Streptomyces sp. CK-4416. HRFAB-MS and NMR analyses reveal that molecular formulae of CKD-711 and CKD-711a are C25H43NO20 and C37H63NO30, respectively with the latter containing two more glucose moieties than the former. Detailed chemical structures of both compounds have been characterized by high-resolution two-dimensional NMR methods.
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| http://dx.doi.org/10.7164/antibiotics.55.467 | DOI Listing |
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