Numerous natural products have been used as traditional abortifacients, each with their own efficacy and adverse effects. With the continued growth of the natural products industry, clinicians are more likely to see adverse effects from attempted abortions using these agents. A 21-y-old female developed tachycardia, diaphoresis, abdominal pain, vomiting and muscle weakness and fasciculations after using blue cohosh (Caulophyllum thalictroides) in an attempt to induce an abortion. These symptoms are consistent with nicotinic toxicity and probably resulted from methylcytisine known present in blue cohosh. The patient's symptoms resolved over 24 h and she was discharged. Whether successful or not, the use of natural agents to induce abortion is frequently associated with adverse effects in the mother or fetus. Clinicians should recognize the potential toxicity of these agents.
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J Ethnopharmacol
January 2025
The key laboratory of pathobiology on the tumors with high incidence in Ethics area, State Ethnic Affairs Commission; Cancer Research Center of Yanbian University, Yanji, China. Electronic address:
Ethnopharmacological Relevance: Caulophyllumrobustum Maxim extract (CRME), as recorded in traditional Chinese medicine, has the function of dispelling Feng, regulating Qi and dredging collaterals, promoting blood circulation and regulating menstruation, gingering up and relieving pain, clearing heat simultaneously detoxifying, lowering blood pressure and hemostasis. CRME is often used as Chinese materia medica preparation for rheumatoid arthritis, traumatic injury, irregular menstruation, abdominal pain, and hypertension treatment. Since gastric cancer (GC) existed as a health problem of human over the years, we are committed to the development of potential components of Chinese herbal medicine curing cancer, and we found CRME is expected to be one of the effective anti-tumor traditional Chinese medicine preparations.
View Article and Find Full Text PDFNat Prod Res
June 2024
School of Pharmaceutical Sciences, South-Central Minzu University, Wuhan, Hubei, China.
Eleven oleanane triterpenoids (-) including two new ones ( and ) were isolated from the roots and stems of . Their structures were established by extensive spectroscopic analysis, comparison with literature, and NMR calculations. Compounds and represent the first examples of 23-hydroxy-28--oleanane and 21-hydroxy-olean-3-one triterpenoids, respectively.
View Article and Find Full Text PDFFood Chem Toxicol
February 2024
Neurotoxicology Research Group, Division of Toxicology, Institute for Risk Assessment Sciences (IRAS), Faculty of Veterinary Medicine, Utrecht University, P.O. Box 80.177, NL-3508 TD Utrecht, the Netherlands. Electronic address:
Toxicity testing of botanicals is challenging because of their chemical complexity and variability. Since botanicals may affect many different modes of action involved in neuronal function, we used microelectrode array (MEA) recordings of primary rat cortical cultures to screen 16 different botanical extracts for their effects on cell viability and neuronal network function in vitro. Our results demonstrate that extract materials (50 μg/mL) derived from goldenseal, milk thistle, tripterygium, and yohimbe decrease mitochondrial activity following 7 days exposure, indicative of cytotoxicity.
View Article and Find Full Text PDFGenes Genomics
March 2024
Department of Smart Farm and Agricultural Industry, Kangwon National University, Chuncheon, 24341, Republic of Korea.
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