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Resveratrol promotes cholesterol efflux from dendritic cells and controls costimulation and T-cell activation in high-fat and lipopolysaccharide-driven atherosclerotic mice.
Front Cardiovasc Med
December 2024
School of Pharmacy, Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
Cholesterol aggregation in dendritic cells (DCs) triggers an inflammatory response and accelerates the development of atherosclerosis (AS). Resveratrol (RES), a natural compound with anti-inflammatory and cholesterol metabolism regulatory properties, has been shown to influence the maturation and inflammatory functions of DCs. However, its relationship with cholesterol metabolism remains unclear.
View Article and Find Full Text PDFPotential of water sediments in construction materials: Current approaches and critical consideration of future challenges.
Heliyon
January 2025
Department of Materials Engineering and Chemistry, Faculty of Civil Engineering, Czech Technical University in Prague, Thákurova 7, 166 29, Prague 6, Czech Republic.
Human activities result in sediment accumulation, so the reservoirs gradually lose their functionality, impacting their ability to manage large flood inflows, supply water, and generate hydroelectric power. Therefore, periodic removal of sediments from water reservoirs is essential to maintain functionality. Notwithstanding, the management of dredged sediments is a multifaceted process that involves careful consideration of environmental, regulatory, and economic factors to ensure their responsibility and sustainable handling.
View Article and Find Full Text PDFWTAP Promotes Atherosclerosis by Inducing Macrophage Pyroptosis and M1 Polarization through Upregulating NLRP3.
Appl Biochem Biotechnol
January 2025
University of South China, Hengyang, Hunan, China.
The study was designed to investigate the impact of N6-methyladenosine (m6A) writer Wilms tumor 1-associated protein (WTAP) on the progression of atherosclerosis (AS) and to further elucidate its possible regulatory mechanism. The m6A levels and WTAP expressions were initially assessed through RIP, qRT-PCR, and western blotting. An in vitro model of AS was constructed by ox-LDL treatment in RAW264.
View Article and Find Full Text PDFInvestigation of Microbial Quality of Milk and Milk Products and Isolations of Some Major Bacteria in the Central and Northwestern Zones of Tigray, Ethiopia.
Vet Med Int
December 2024
Department of Biology, Aksum University, Axum, Ethiopia.
Safety and quality of milk and milk products are an increasing concern worldwide. Milk and milk products are major causes of milk-borne diseases due to contamination with microorganisms resulting from a lack of standard milk handling procedures and hygienic practices. Thus, the study aims to investigate the microbial quality and safety of cow milk and milk products and isolate some bacteria in Tigray.
View Article and Find Full Text PDFThe transcription factor YbdO attenuates the pathogenicity of avian pathogenic Escherichia coli by regulating oxidative stress response.
BMC Microbiol
December 2024
College of Agriculture and Forestry, Linyi University, Linyi, 276005, Shandong, China.
Avian pathogenic Escherichia coli (APEC) is a significant pathogen infecting poultry that is responsible for high mortality, morbidity and severe economic losses to the poultry industry globally, posing a substantial risk to the health of poultry. APEC encounters reactive oxygen species (ROS) during the infection process and thus has evolved antioxidant defense mechanisms to protect against oxidative damage. The imbalance of ROS production and antioxidant defenses is known as oxidative stress, which results in oxidative damage to proteins, lipids and DNA, and even bacterial cell death.
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