Multifocal motor neuropathy and Campylobacter jejuni reactivity.

Neurology

Giorgio Spagnol Service of Clinical Neuroimmunology, Department of Neurological Sciences, Dino Ferrari Center, Milan University, IRCCS Ospedale Maggiore Policlinico, Milan, Italy.

Published: July 2002

In some patients, Campylobacter jejuni infection has been associated with the development of multifocal motor neuropathy (MMN) and high titers of antiganglioside antibodies. The authors measured anti-C. jejuni antibodies by ELISA and immunoblot in 20 patients with MMN, and correlated their presence with antiganglioside reactivity and a history of recent diarrhea. Only one patient had high titers of anti-C. jejuni antibodies, indicating that C. jejuni is unlikely to be involved in the pathogenesis of MMN in most patients.

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http://dx.doi.org/10.1212/wnl.59.2.282DOI Listing

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