AI Article Synopsis
- The Inos2 DDDR pacemaker adjusts heart rate based on unipolar intracardiac impedance signals to meet physical activity needs.
- Twelve patients with chronotropic incompetence were tested during a stress echocardiography using dobutamine, which is a medication that increases heart rate.
- Results showed that the pacemaker effectively increased heart rates without any signs of excessive positive feedback that could complicate heart function.
Article Abstract
Background: The Inos2 DDDR pacemaker senses unipolar intracardiac impedance signals for adapting heart rate to meet the haemodynamic needs of physical activity. Theoretically, such pacing devices could be limited by positive feedback since increase in beating frequency per se enhances contractility. We have addressed this problem in patients with chronotropic incompetence who were subjected to a pharmacological stress test.
Methods And Results: Twelve patients with chronically implanted Inos2 DDDR pacemakers were studied using the standard protocol of stress echocardiography. Most of the patients reached the programmable maximum closed-loop rate during the incremental dobutamine challenge. The time courses for increase in as well as for recovery of heart rate were not different from control patients receiving routine diagnostic stress echocardiography.
Conclusions: In patients implanted with the Inos2 DDDR pacemaker acute stimulation with intravenous dobutamine leads to a robust increase in paced heart rate without any evidence of positive feedback.
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| http://dx.doi.org/10.1053/eupc.2002.0235 | DOI Listing |
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