[Searching for the susceptibility loci of psoriasis in Chinese].

Objective: To search for the susceptibility genes of patients with psoriasis in Chinese.

Methods: 38 psoriasis families were determined to search for the susceptibility loci by selecting 19 reported polymorphic microsatellite DNA markers and making use of fluorescein-labeled PCR with Mega BACE sequencer.

Results: The significant two-point Lod score values of parametric linkage analysis were obtained with D6S1610 marker (1.18 at theta; = 0.2) and D17S944 marker (1.60 at theta; = 0.1); the NPL values greater than 1.6 (P < 0.05) of non-parametric analysis were obtained with D6S1610 marker, D17S944 marker and D17S785 marker.

Conclusion: A putative linkage to D6S1610 marker, D17S944 marker and D17S785 marker.