The authors retrospectively analyzed the files of 11 patients with osteochondral sequelae of meningococcemia, which were referred to this service between 1988 and 1996. The purpose of this study was to radiographically evaluate bone and physeal injuries observed in these patients, deformities caused by them and correlate these findings with the current literature. During radiographic evaluation of patients with sequelae of meningococcemia, two distinct parameters should be observed: bone injury and physeal plate injury patterns. The most frequent bone injury pattern was lytic lesion and the most common physeal plate injury pattern was peripheral asymmetric physis destruction. The most frequent deformities were lower limb length discrepancy, angular deformities and digital amputations. Based upon the findings of the present research, a descriptive radiographic classification was proposed.
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Epidemiol Mikrobiol Imunol
December 2024
Invasive meningococcal diseases (IMD) caused by Neisseria meningitidis are generally rare. They affect mostly selected age categories and risk groups of patients (in terms of age, comorbidities, or applied therapy), and the immune system and its defects may play an important modifying role. Meningococcal infections could be the first and only clinical sign of unrecognised immunodeficiency.
View Article and Find Full Text PDFHum Vaccin Immunother
December 2024
Real-World Evidence, Evidera, Waltham, MA, USA.
Invasive meningococcal disease (IMD) is a life-threatening yet vaccine-preventable disease, with vaccines approved and recommended in the United States by the Centers for Disease Control and Prevention. This study assessed complications, mortality, healthcare resource utilization (HCRU), and healthcare costs among a sample of commercially-insured individuals living in the United States who experienced IMD. We used retrospective data from large claims databases limited to individuals with IMD covered by commercial health plans between January 2010-March 2022.
View Article and Find Full Text PDFHaematologica
November 2024
Department of Haematological Medicine, King's College Hospital NHS Foundation Trust, London, UK; Red Cell Haematology, Comprehensive Cancer Centre, School of Cancer and Pharmaceutical Sciences, King's College London, London.
Sickle cell disease (SCD) is one of the commonest severe inherited disorders in the world. Infection accounts for a significant amount of the morbidity and mortality, particularly in sub- Saharan Africa, but is relatively poorly studied and characterized. Patients with SCD have significant immunodeficiency and are more likely to suffer severe and life-threatening complications of infection, and additionally infections can trigger complications of SCD itself.
View Article and Find Full Text PDFInfect Dis Ther
December 2024
IQVIA, London, UK.
Rev Prat
October 2024
Professeure honoraire de pédiatrie, Université Paris-Cité ; membre du Groupe de pathologie infectieuse pédiatrique (GPIP) ; membre d'Infovac France ; Trustee de la « Coalition for Life Course Immunisation » (« CLCI »).
AFTER-EFFECTS OF INVASIVE MENINGOCOCCAL DISEASES. Invasive meningococcal infections (IMI) still have a mortality rate of 11% in France. Recent nationwide studies have been able to quantify the long-term sequelae among survivors and highlight their diversity.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!