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Persistent microbial infections and idiopathic pulmonary fibrosis - an insight into pathogenesis.
Front Cell Infect Microbiol
January 2025
Center for Metabolic and Degenerative Diseases, The Brown Foundation Institute of Molecular Medicine for Prevention of Human Diseases, UTHealth-McGovern Medical School, Houston, TX, United States.
Interstitial lung disease (ILD) is characterized by chronic inflammation and scarring of the lungs, of which idiopathic pulmonary fibrosis (IPF) is the most devastating pathologic form. Idiopathic pulmonary fibrosis pathogenesis leads to loss of lung function and eventual death in 50% of patients, making it the leading cause of ILD-associated mortality worldwide. Persistent and subclinical microbial infections are implicated in the acute exacerbation of chronic lung diseases.
View Article and Find Full Text PDFMagnetic resonance imaging in idiopathic inflammatory myopathies: deciphering the pattern of muscle involvement.
Neuromuscul Disord
November 2024
Department of Neurology, Neuroscience Faculty Center, National Institute of Mental Health and Neurosciences (NIMHANS), Bengaluru 560029, India. Electronic address:
Idiopathic inflammatory myopathies (IIMs) constitute a group of immune-mediated disorders, affecting muscles. Our study aims to investigate the specific patterns of muscle involvement in subgroups of IIM. An ambispective and observational study was conducted.
View Article and Find Full Text PDFSemimechanistic Population PK/PD Modeling of Axatilimab in Healthy Participants and Patients With Solid Tumors or Chronic Graft-Versus-Host Disease.
Clin Pharmacol Ther
December 2024
Incyte Corporation, Wilmington, Delaware, USA.
Article Synopsis
- Axatilimab is a monoclonal antibody that targets CSF-1R, approved for treating chronic graft-versus-host disease (cGVHD) and being researched for other conditions like idiopathic pulmonary fibrosis.
- A study involving 325 participants investigated the drug's pharmacokinetics (PK) and pharmacodynamics (PD), showing that it reduces certain immune cell levels, which affects enzyme levels in the bloodstream.
- The final PK/PD model, based on complex math involving differential equations, identified several factors influencing axatilimab's effectiveness and helped shape dosing strategies for cGVHD patients.
Single-cell RNA sequencing of chronic idiopathic erythroderma defines disease-specific markers.
J Allergy Clin Immunol
December 2024
Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, NY. Electronic address:
Background: Chronic erythroderma is a potentially life-threatening condition that can be caused by various diseases, but approximately 30% of cases remain idiopathic, often with insufficient treatment options.
Objective: We sought to establish a molecular disease map of chronic idiopathic erythroderma (CIE).
Methods: We performed single-cell RNA sequencing combined with T-cell receptor sequencing of blood and skin from 5 patients with CIE and compared results with 8 cases of erythrodermic cutaneous T-cell lymphoma (eCTCL), 15 cases of moderate to severe atopic dermatitis, 10 cases of psoriasis, and 20 healthy control individuals.
Intramural Ventricular Arrhythmias: How to Crack a Hard Nut.
Curr Cardiol Rep
December 2024
Section of Cardiac Electrophysiology, Hospital of the University of Pennsylvania, 1 Convention Avenue, Philadelphia, Pennsylvania, 19104, USA.
Article Synopsis
- * Mapping procedures, especially in regions like the left ventricular ostium and interventricular septum, are essential for pinpointing intramural arrhythmias and planning appropriate ablation strategies.
- * Advanced techniques, such as bipolar ablation or transvenous ethanol injection, may be necessary during ablation, highlighting the importance of comprehensive mapping that includes the coronary venous system.
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