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Differentiation of stem cells into chondrocytes and their potential clinical application in cartilage regeneration.
Histochem Cell Biol
January 2025
Department of Forensic Medicine and Forensic Toxicology, Medical University of Silesia, 18 Medyków Street, 40-752, Katowice, Poland.
Cartilage diseases and injuries are considered difficult to treat owing to the low regenerative capacity of this tissue. Using stem cells (SCs) is one of the potential methods of treating cartilage defects and creating functional cartilage models for transplants. Their ability to proliferate and to generate functional chondrocytes, a natural tissue environment, and extracellular cartilage matrix, makes SCs a new opportunity for patients with articular injuries or incurable diseases, such as osteoarthritis (OA).
View Article and Find Full Text PDFBasic Considerations for Data Pooling Strategy in Multi-Regional Clinical Trials (MRCTs).
Ther Innov Regul Sci
January 2025
Department of Biostatistics, School of Public Health, Peking University, Beijing, China.
The National Medical Products Administration of China has been implementing ICH E17, which describes the general principles for planning and designing of multi-regional clinical trials (MRCTs), yet there are several ambiguities in the execution and conduct remains in China or East Asia. In specific, pooling strategy, effect modifiers (EMs), statistical analysis, sample size allocation and their impact in alignment with global trial remains a challenge. In this paper, we explore on the criteria mentioned above under the context of China.
View Article and Find Full Text PDFEffects of Electronic Cigarettes on Periodontal Health: A Systematic Review and Meta-Analysis.
Int Dent J
January 2025
Research and Graduate Studies Department, Mohammed Bin Rashin University of Medicine and Health Sciences, Dubai, UAE. Electronic address:
Objectives: The use of electronic cigarettes "e-cigarettes," or vaping is growing in popularity, especially among adolescents and young adults. While the effects of cigarette smoking on oral health are well-established, the exact impact that e-cigarettes may have on dental tissues is still uncertain. The aim of the current review was to summarize evidence related to the effect of vaping on the periodontal health status of e-cigarette users.
View Article and Find Full Text PDFSingular topological edge states in locally resonant metamaterials.
Sci Bull (Beijing)
January 2025
Department of Mechanical Engineering, Pohang University of Science and Technology (POSTECH), Pohang 37673, Republic of Korea; Department of Chemical Engineering, Pohang University of Science and Technology (POSTECH), Pohang 37673, Republic of Korea; Department of Electrical Engineering, Pohang University of Science and Technology (POSTECH), Pohang 37673, Republic of Korea; POSCO-POSTECH-RIST Convergence Research Center for Flat Optics and Metaphotonics, Pohang 37673, Republic of Korea. Electronic address:
Band topology has emerged as a novel tool for material design across various domains, including photonic and phononic systems, and metamaterials. A prominent model for band topology is the Su-Schrieffer-Heeger (SSH) chain, which reveals topological in-gap states within Bragg-type gaps (BG) formed by periodic modification. Apart from classical BGs, another mechanism for bandgap formation in metamaterials involves strong coupling between local resonances and propagating waves, resulting in a local resonance-induced bandgap (LRG).
View Article and Find Full Text PDFHuman cancer cells xenografts to assess the efficacy of granulysin-based therapeutics.
Methods Cell Biol
January 2025
Apoptosis, Immunity and Cancer Group, Aragón Health Research Institute (IIS-Aragón), University of Zaragoza, Zaragoza, Spain. Electronic address:
9-kDa Granulysin is a protein present in the granules of human activated cytotoxic T lymphocytes and natural killer cells. It has been shown to exert cytolytic activity against a wide variety of microbes: bacteria, fungi, yeast and protozoa. Recombinant isolated granulysin is also capable of inducing tumor cell death, so it could be used as an anti-tumor therapy.
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