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Eye reactions under the influence of drugs of abuse as measured by smartphones: a controlled clinical study in healthy volunteers.
Front Neurosci
January 2025
Kontigo Care AB, Uppsala, Sweden.
Background: It is known that illicit and prescribed drugs impact pupil size, eye movement and function. Still, comprehensive quantitative evaluations under known ambient light conditions are lacking, when smartphones are used for monitoring.
Methods: In this clinical study (NCT05731999), four medicinal products with addiction risks were administered to 48 subjects (18-70 years old, all with informed consent, 12 subjects per drug).
Opioid use in treated and untreated obstructive sleep apnoea: remifentanil pharmacokinetics and pharmacodynamics in adult volunteers.
Br J Anaesth
January 2025
Department of Anesthesiology, Duke University School of Medicine, Durham, NC, USA; Bermaride LLC, Durham, NC, USA. Electronic address:
Background: Patients with obstructive sleep apnoea (OSA) are considered more sensitive to opioids and at increased risk of opioid-induced respiratory depression. Nonetheless, whether OSA treatment (continuous positive airway pressure, CPAP; or bilevel positive airway pressure, BIPAP) modifies this risk remains unknown. Greater opioid sensitivity can arise from altered pharmacokinetics or pharmacodynamics.
View Article and Find Full Text PDFComa and confirmed epileptiform activity induced by Amanita pantherina poisoning.
Toxicon
January 2025
Bergamo Poison Center, ASST Papa Giovanni XXIII Hospital, Bergamo, Italy.
Amanita pantherina poisoning is a rare event poorly described. The clinical picture is usually associated with the one of A. muscaria, but A.
View Article and Find Full Text PDFManaging Amitraz Poisoning: Epidemiological Data and Clinical Insights From a Tertiary Care Hospital in Southern India.
Cureus
November 2024
Medical Oncology, Kidwai Memorial Institute of Oncology, Bengaluru, IND.
Background Amitraz is a formamidine insecticide and acaricide that acts on α2 adrenergic receptors. There is limited information in the literature regarding the toxicity of this compound and treatment of poisoning. Here, we have studied the epidemiology, symptoms, signs, complications, abnormalities in the tests, management, and prognosis of individuals who were admitted to a tertiary care hospital with acute amitraz intoxication.
View Article and Find Full Text PDFDiagnosis of Acute Glaucoma Attack Using a Quantitative Pupillometer: A Case Report.
Cureus
November 2024
Department of Internal Medicine/Division of Emergency Medicine, Toho University Sakura Medical Center, Chiba, JPN.
Acute glaucoma attacks cause a sudden increase in intraocular pressure. In addition to ocular symptoms such as redness, visual impairment, and eye pain, it also presents with headache and vomiting. It is diagnosed using a slit lamp microscope, gonioscope, and anterior segment optical coherence tomography.
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