AI Article Synopsis
- The study focuses on creating new compounds called 3-aryl pyrazolo[4,3-d]pyrimidines that may block the action of the corticotropin-releasing factor (CRF-1) receptor.
- Researchers examined how different chemical substitutions on the aromatic ring, amino group, and pyrazolo ring influenced their ability to bind to the CRF-1 receptor.
- The findings aim to contribute to the development of potential treatments for conditions related to CRF-1 signaling.
Article Abstract
The synthesis of a series of 3-aryl pyrazolo[4,3-d]pyrimidines as potential corticotropin-releasing factor (CRF-1) antagonists is described. The effects of substitution on the aromatic ring, the amino group and the pyrazolo ring on CRF-1 receptor binding were investigated.
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| http://dx.doi.org/10.1016/s0960-894x(02)00358-x | DOI Listing |
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