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Severe central nervous system injury in 9 children with COVID-19.
BMC Pediatr
January 2025
Department of Pediatrics, Affiliated Hospital of Jining Medical University, Jining, 272007, Shandong, China.
Purpose: To investigate the clinical features and prognosis of severe central nervous system (CNS) injury in children caused by coronavirus disease 2019 (COVID-19).
Method: We retrospectively studied confirmed pediatric cases of COVID-19 complicated with CNS injury.
Results: Nine patients diagnosed with COVID-19 complicated with severe CNS injury were admitted to the pediatric intensive care unit of the Affiliated Hospital of Jining University from December 1, 2022 to January 12, 2023.
Mechanical finite element analysis of needle tip shape to develop insertable polymer-based microneedle without plastic deformation.
J Mech Behav Biomed Mater
January 2025
Department of Materials Engineering, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8656, Japan; Innovation Center of NanoMedicine (iCONM), 3-25-14 Tonomachi, Kawasaki, Kanagawa, 210-0821, Japan.
Bioabsorbable polymer microneedles are highly attractive as modernized medical devices for efficient yet safe transdermal drug delivery and biofluid biopsy. In this study, the elastoplastic deformation of polymer microneedles, having a high aspect ratio (over 5-10), is investigated using poly(lactic) acid polymer approved by the United States Food and Drug Administration to be generally considered safe. Microneedle geometries are comprehensively analyzed for tip geometries comprising the tip diameter (ϕ) and tip taper length (l) of 100 designs.
View Article and Find Full Text PDFPrimary breast Burkitt lymphoma with lactic acidosis in a child: a case report.
Turk J Pediatr
December 2024
Department of Pathology, Faculty of Medicine, Hacettepe University, Ankara, Türkiye.
Background: Primary breast lymphoma is extremely rare and constitutes approximately 1% of all non-Hodgkin's lymphomas (NHL). Only 1-5% of them are Burkitt type. We present a case of childhood primary breast Burkitt lymphoma (BL).
View Article and Find Full Text PDFPrediagnostic Plasma Nutrimetabolomics and Prostate Cancer Risk: A Nested Case-Control Analysis Within the EPIC Study.
Cancers (Basel)
December 2024
Unit of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO), Bellvitge Biomedical Research Institute (IDIBELL), 08908 Barcelona, Spain.
: Nutrimetabolomics may reveal novel insights into early metabolic alterations and the role of dietary exposures on prostate cancer (PCa) risk. We aimed to prospectively investigate the associations between plasma metabolite concentrations and PCa risk, including clinically relevant tumor subtypes. : We used a targeted and large-scale metabolomics approach to analyze plasma samples of 851 matched PCa case-control pairs from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.
View Article and Find Full Text PDFA Rare Case of Metformin-Induced Lactic Acidosis and Concomitant Euglycemic Ketoacidosis.
Cureus
November 2024
Internal Medicine, Wright State University, Dayton, USA.
Acidemia arises primarily from the accumulation of carbon dioxide or the loss of bicarbonate, leading to a pH decrease within the body, which can be fatal if severe and not promptly addressed. Metabolic acidemia occurs due to a loss of bicarbonate and can manifest through direct losses of bicarbonate via renal or gastrointestinal routes, or through the accumulation of anions such as lactic acid or ketoacids, leading to an anion gap metabolic acidosis. Many common etiologies for lactic acid and ketoacid generation exist, including medication-induced causes.
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