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A Glimpse for the subsistence from pandemic SARS-CoV-2 infection.
Bioorg Chem
November 2024
School of Pharmaceuticals and Population Health Informatics, Faculty of Pharmacy, DIT University, Dehradun, Uttarakhand, 248009, India.
COVID-19 is an emerging viral pandemic caused by SARS-CoV-2, which is the causative agent of unprecedented disease-causing public health threats globally. Worldwide, this outbreak is wreaking havoc due to failure in risk assessment regarding the urgency of the pandemic. As per the reports, many secondary complications which include neurological, nephrological, gastrointestinal, cardiovascular, immune, and hepatic abnormalities, are linked with COVID -19 infection which is associated with prominent respiratory disorders including pneumonia.
View Article and Find Full Text PDFA Scoping Review of Arthropod-Borne Flavivirus Infections in Solid Organ Transplant Recipients.
Transpl Infect Dis
December 2024
Department of Medicine, Division of Infectious Diseases, Cooper Medical School of Rowan University, Camden, New Jersey, USA.
Arthropod-borne flaviviruses (ABFs), transmitted by mosquitoes or ticks, are increasing due to climate change and globalization. This scoping review examines the epidemiology, clinical characteristics, diagnostics, treatment, and outcomes of ABF infection in solid organ transplant recipients (SOTRs). A database search up to January 25, 2024, focused on ABFs such as West Nile virus (WNV), dengue virus (DENV), Japanese encephalitis virus (JEV), Powassan virus (POWV), yellow fever virus (YFV), and Zika virus (ZIKV), limited to SOTRs.
View Article and Find Full Text PDFAcute effects of interferon-alpha on cellular anabolic and catabolic processes are associated with the development of fatigue during Interferon-alpha-based therapy for Hepatitis-C: A preliminary study.
Brain Behav Immun
January 2025
CUBRIC, Cardiff University Brain Research Imaging Centre, Cardiff, UK; Clinical Imaging Sciences Centre, Brighton and Sussex Medical School, Brighton, UK.
Introduction: Interferon-alpha (IFN-α) is a key mediator of antiviral immune responses used to treat Hepatitis-C virus (HCV) infection. Though clinically effective, IFN-α frequently induces functionally impairing mood and motivation symptoms, particularly fatigue. Unlike mood impairment, which typically emerges after weeks of treatment, fatigue tends to emerge and evolve rapidly, typically within hours of the first IFN-α injection.
View Article and Find Full Text PDFThe Impact of the G6PD Gene Mutations in Patients with Chronic Hepatitis C Infection Treated with Direct-Acting Antivirals: A Multicenter Observational Study.
Genes (Basel)
August 2024
Internal Medicine Unit, Maggiore della Carità Hospital, 28100 Novara, Italy.
Article Synopsis
- Direct-acting antivirals (DAAs) have made hepatitis C treatment much easier, but there’s limited info on how they work for patients with glucose-6-phosphate dehydrogenase deficiency (G6PDd).
- A study looked at 2754 HCV-positive patients from 2015 to 2023, focusing on 38 with confirmed G6PDd, while monitoring their health closely during and after treatment.
- Results showed no significant health issues or adverse events related to the treatment, with effectiveness similar to those without G6PDd, indicating that DAAs are safe for HCV treatment in these patients.
From discovery to treatment: tracing the path of hepatitis E virus.
Virol J
August 2024
Department of Virology, Faculty of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
The hepatitis E virus (HEV) is a major cause of acute viral hepatitis worldwide. HEV is classified into eight genotypes, labeled HEV-1 through HEV-8. Genotypes 1 and 2 exclusively infect humans, while genotypes 3, 4, and 7 can infect both humans and animals.
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