Ketamine hydrochloride is commonly employed to sedate or anesthetize laboratory primates but its cardiac actions have not been previously described in these animals. Four baboons, Papio cynocephalus, were chronically instrumented with electromagnetic flow detectors on the ascending aorta and common carotid artery. Cardiac output, peak aortic flow velocity and peak aortic flow acceleration are all depressed by Ketamine, 5 mg/kg i.m. Peak aortic flow acceleration and peak carotid flow acceleration were equally depressed. Thus, peak carotid flow acceleration is a useful indirect index of the left ventricular response to Ketamine in the baboon.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Effect of application of the thoracoabdominal rebalancing (TAR) method in moderate premature children: randomized and controlled clinical trial.
Rev Paul Pediatr
January 2025
Universidade Federal de Alfenas - Alfenas (MG), Brazil.
Objective: To analyze the effect of the thoracoabdominal rebalancing (TAR) method on respiratory biomechanics, respiratory discomfort, pain sensation, and physiological parameters in moderate preterm newborns, compared to a control group.
Methods: This randomized clinical trial was conducted in a neonatal intensive care unit. The evaluation included: Neonatal Infant Pain Scale, physiological parameters, Silverman-Andersen score, and biomechanics (thoracic cirtometry and Charpy angle).
Endothelial cells under disturbed flow release extracellular vesicles to promote inflammatory polarization of macrophages and accelerate atherosclerosis.
BMC Biol
January 2025
Institute of Biomedical Engineering, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu, 610041, China.
Background: Extracellular vesicles (EVs) derived from endothelial cells (ECs) are increasingly recognized for their role in the initiation and progression of atherosclerosis. ECs experience varying degrees and types of blood flow depending on their specific arterial locations. In regions of disturbed flow, which are predominant sites for atherosclerotic plaque formation, the impact of disturbed flow on the secretion and function of ECs-derived EVs remains unclear.
View Article and Find Full Text PDFIntegrating microfluidics, hydrogels, and 3D bioprinting for personalized vessel-on-a-chip platforms.
Biomater Sci
January 2025
School of Biomedical Engineering, The University of Sydney, Darlington, NSW 2008, Australia.
Thrombosis, a major cause of morbidity and mortality worldwide, presents a complex challenge in cardiovascular medicine due to the intricacy of clotting mechanisms in living organisms. Traditional research approaches, including clinical studies and animal models, often yield conflicting results due to the inability to control variables in these complex systems, highlighting the need for more precise investigative tools. This review explores the evolution of thrombosis models, from conventional polydimethylsiloxane (PDMS)-based microfluidic devices to advanced hydrogel-based systems and cutting-edge 3D bioprinted vascular constructs.
View Article and Find Full Text PDFNKX6.3 modulation of mitotic dynamics and genomic stability in gastric carcinogenesis.
Cell Commun Signal
January 2025
Department of Pathology, Functional RNomics Research Center, College of Medicine, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul, 06591, South Korea.
Background: Gastric cancer remains a significant global health challenge, characterized by poor prognosis and high mortality rates. Mitotic integrity and genomic stability are crucial in maintaining cellular homeostasis and preventing tumorigenesis. The transcription factor NKX6.
View Article and Find Full Text PDFImproving the Stability of Gas Diffusion Electrodes for CO Electroreduction to Formate with Sn and In-Based Catalysts at 500 mA cm: Effect of Electrode Design and Operation Mode.
ACS Omega
January 2025
Department of Chemical and Biological Engineering, The University of British Columbia, 2360 East Mall, Vancouver V6T 1Z3, Canada.
The electrochemical carbon dioxide reduction reaction (CORR) using renewable electricity sources could provide a sustainable solution for generating valuable chemicals, such as formate salt or formic acid. However, an efficient, stable, and scalable electrode generating formate at industrially viable current densities (>100 mA cm) is yet to be developed. Sn or In-based catalysts in gas diffusion electrodes (GDE) can efficiently produce formate.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!