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The rat osteoarthritis bone score for histological pathology relevant to human bone marrow lesions and pain.
Osteoarthr Cartil Open
March 2025
Pain Centre Versus Arthritis and Academic Unit of Injury, Recovery and Inflammation Sciences, University of Nottingham, UK.
Objectives: Histological osteochondral characteristics of inflammation, fibrosis, vascularity, cartilage islands, vessels entering cartilage, thickened trabeculae and cysts are associated with bone marrow lesions (BMLs) in human knee osteoarthritis (OA). We identified and developed a method for scoring comparable pathology in two rat OA knee pain models.
Methods: Rats (n = 8-10 per group) were injected with monoiodoacetate (MIA) or saline, or underwent meniscal transection (MNX) or sham surgery.
Operative Repair of Medial Patellofemoral Ligament Injury Versus Knee Bracing in Acute First-Time Traumatic Patellar Dislocation: A Systematic Review and Meta-Analysis.
Cureus
November 2024
Pharmacy, Kafr El Sheikh Hospital, Kafr El Sheikh, EGY.
Acute first-time traumatic patellar dislocation is a prevalent knee injury, particularly in adolescents, often managed conservatively with knee bracing. Recently, medial patellofemoral ligament (MPFL) reconstruction has gained popularity for its potential benefits in reducing redislocation rates and enhancing functional outcomes. This systematic review and meta-analysis compared the outcomes of MPFL reconstruction versus knee bracing for managing acute first-time traumatic patellar dislocation.
View Article and Find Full Text PDFBiomechanical Evaluation and Comparative Analysis of Functional Scores in Suture Anchor Versus Transosseous Tunnel Patellar Tendon Repair Techniques in Adult Patients: A Systematic Review and Meta-Analysis.
Cureus
November 2024
General Surgery, King's Mill Hospital, Nottingham, GBR.
Patellar tendon injuries, although less frequent than other knee injuries, can have a profound impact on knee function, often leading to significant disability. Among the various surgical techniques employed to repair these injuries, the suture anchor and transosseous tunnel methods are the most commonly used. This systematic review and meta-analysis compares the biomechanical properties and functional outcomes of these two repair techniques.
View Article and Find Full Text PDFDevelopment of methodology to support molecular endotype discovery from synovial fluid of individuals with knee osteoarthritis: The STEpUP OA consortium.
PLoS One
November 2024
Centre for Osteoarthritis Pathogenesis Versus Arthritis, Kennedy Institute of Rheumatology, NDORMS, University of Oxford, Oxford, United Kingdom.
Objectives: To develop a protocol for largescale analysis of synovial fluid proteins, for the identification of biological networks associated with subtypes of osteoarthritis.
Methods: Synovial Fluid To detect molecular Endotypes by Unbiased Proteomics in Osteoarthritis (STEpUP OA) is an international consortium utilising clinical data (capturing pain, radiographic severity and demographic features) and knee synovial fluid from 17 participating cohorts. 1746 samples from 1650 individuals comprising OA, joint injury, healthy and inflammatory arthritis controls, divided into discovery (n = 1045) and replication (n = 701) datasets, were analysed by SomaScan Discovery Plex V4.
Evaluating functional ability in older adults' object retrieval behavior from kitchen furniture using OpenPose and REBA.
Sci Rep
October 2024
School of Art and Design, Nottingham Trent University, Nottingham, NG1 4FQ, UK.
The purpose of this study is to evaluate, through analysis, the ability of older persons to retrieve items from kitchen cabinets. To achieve this goal, data were collected from 128 valid questionnaires and supplemented with field research and user interviews. The study revealed that the elderly's behavior in retrieving items from kitchen spaces is characterized by both high frequency and difficulty.
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