Tributylphosphine: a remarkable promoting reagent for the ring-opening reaction of aziridines.

J Org Chem

Shanghai-Hong Kong Joint Laboratory in Chemical Synthesis and State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Science, 354 Fenglin Road, Shanghai 200032, China.

Published: July 2002

Tributylphosphine was found to be an effective promoting reagent for ring opening of a variety of aziridines and nucleophiles to produce anti-bifunctional products in good to excellent yield. The study showed that the reaction is initiated through the attack of tributylphosphine as a nucleophile at the carbon atom of the aziridine ring.

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Source
http://dx.doi.org/10.1021/jo016230tDOI Listing

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