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Toxicity study of Stachybotrys chartarum (CASRN 67892-26-6) administered by inhalation to B6C3F1/N mice.
Toxic Rep Ser
October 2024
Division of Translational Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA.
Stachybotrys chartarum, also known as "black mold," is a cellulolytic saprophyte with a worldwide distribution. Public concern for potential illnesses associated with water-damaged indoor environments has been heightened since the report of pediatric acute idiopathic pulmonary hemorrhage/hemosiderosis cases in the United States and following recent natural disasters. Although mycotoxicosis and pulmonary immunological endpoints have been previously examined, the systemic toxicity following subchronic inhalation of viable S.
View Article and Find Full Text PDFClinical features and risk factors for recurrence of idiopathic pulmonary hemosiderosis in children.
BMC Pulm Med
September 2024
Division of Pediatric Pulmonology and Immunology, West China Second University Hospital, Sichuan University, Chengdu, 610041, China.
Article Synopsis
- - The study reviewed the clinical features, treatment response, and outcomes of pediatric idiopathic pulmonary hemosiderosis (IPH), aiming to identify recurrence risk factors for better early diagnosis and treatment.
- - Among 32 children studied, common initial symptoms were anemia (90.6%), cough (75%), and hemoptysis (56.2%), with a median diagnosis delay of 5 months; many experienced remission but 19 had relapses mainly due to respiratory infections and medication issues.
- - Key findings indicated that children with a history of allergies were more likely to relapse, and while high-dose corticosteroids were used, they did not significantly lower recurrence rates; cough and anemia were identified as the most prevalent symptoms.
Pulmonary hemorrhagic syndromes.
Pediatr Pulmonol
September 2024
National Heart and Lung Institute, Imperial College, and Imperial Centre for Paediatrics and Child Health, London, UK.
Novel germline STAT3 gain-of-function mutation causes autoimmune diseases and severe growth failure.
J Allergy Clin Immunol Glob
November 2024
Department of Clinical Immunology, Kochi Medical School, Kochi University, Nankoku, Japan.
Article Synopsis
- The study investigates a young boy with severe autoimmune conditions who was found to have a germline gain-of-function mutation in the STAT3 gene through whole-exome sequencing.* -
- Treatment with the targeted therapy tocilizumab led to a reduction in hospital stays and slowed the progression of pulmonary fibrosis, showing promise for managing his condition without increasing steroid use.* -
- The findings suggest that genetic testing and functional analysis of STAT3 mutations are important for diagnosing early-onset autoimmune diseases and for considering targeted treatment options.*
Diffuse alveolar hemorrhage in pediatrics: Etiologies and outcomes.
Pediatr Pulmonol
December 2024
Division of Pulmonary Medicine, Nationwide Children's Hospital, Columbus, Ohio, USA.
Background: Many conditions, including autoimmune disease and idiopathic pulmonary hemosiderosis (IPH), can cause diffuse alveolar hemorrhage (DAH). Little is known about the epidemiology and outcomes in children.
Objectives: This retrospective cohort study sought to describe the etiologies and outcomes of DAH in pediatric patients at a tertiary care center.
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