The synthesis of carbamoylphosphonate silanes (CMPO analogs) designed for sequestering actinide cations in self-assembled monolayers on mesoporous supports (SAMMS) is described.
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Alkoxysilyl derivative of carbamoylphosphonate as a flame retardant modifier of cotton fabrics.
Int J Biol Macromol
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This research describes the synthesis of a silane derivative containing phosphorus and nitrogen atoms, leveraging their synergistic flame retardant effect through the incorporation of a PH bond to the isocyanate moiety. The synthesized silane featured alkoxysilyl groups, facilitating permanent bonds with the cotton fabric surface via hydrolysis. Cotton fabrics were modified using silane solutions of varying concentrations (2.
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J Enzyme Inhib Med Chem
May 2016
a Institute for Drug Research , Hebrew University of Jerusalem, Jerusalem , Israel and.
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View Article and Find Full Text PDFOrally active, antimetastatic, nontoxic diphenyl ether-derived carbamoylphosphonate matrix metalloproteinase inhibitors.
ChemMedChem
August 2011
Institute for Drug Research, The Hebrew University of Jerusalem, School of Pharmacy, P.O. Box 12065, Jerusalem 91120, Israel.
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The Hebrew University of Jerusalem, Faculty of Medicine, The School of Pharmacy, Institute for Drug Research, PO Box 12065, Jerusalem 91120, Israel.
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View Article and Find Full Text PDFCarbamoylphosphonate matrix metalloproteinase inhibitors 6: cis-2-aminocyclohexylcarbamoylphosphonic acid, a novel orally active antimetastatic matrix metalloproteinase-2 selective inhibitor--synthesis and pharmacodynamic and pharmacokinetic analysis.
J Med Chem
March 2008
Department of Pharmaceutics, The Hebrew University of Jerusalem, Jerusalem, Israel.
cis-2-Aminocyclohexylcarbamoylphosphonic acid ( cis-ACCP) was evaluated in vitro and in two in vivo cancer metastasis models. It reduced metastasis formation in mice by approximately 90% when administered by a repetitive once daily dosing regimen of 50 mg/kg via oral or intraperitoneal routes and was nontoxic up to 500 mg/kg, following intraperitoneal administration daily for two weeks. Pharmacokinetic investigation of cis-ACCP in rats revealed distribution restricted into the extracellular fluid, which is the site of action for the antimetastatic activity and rapid elimination ( t 1/2 approximately 19 min) from blood.
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