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Key challenges in exploring the rat as a preclinical neurostimulation model for aortic baroreflex modulation in hypertension.
Hypertens Res
February 2024
Department of Pharmaceutical Sciences, College of Pharmacy, Alfaisal University, Riyadh, Saudi Arabia.
Electrode-based electrophysiological interfaces with peripheral nerves have come a long way since the 1960s, with several neurostimulation applications witnessing widespread clinical implementation since then. In resistant hypertension, previous clinical trials have shown that "carotid" baroreflex stimulation using device-based baroreflex activation therapy (BAT) can effectively lower blood pressure (BP). However, device-based "aortic" baroreflex stimulation remains untouched for clinical translation.
View Article and Find Full Text PDFThe effect of stimulation and unloading of baroreceptors on cough in experimental conditions.
Respir Physiol Neurobiol
September 2022
Department of Pathological Physiology, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Slovak Republic; Centre for Medical Education Support, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Slovak Republic. Electronic address:
Cough, the main airway defensive process, is modulated by multiple sensory inputs from the respiratory system and outside of it. This modulation is one of the mechanisms that contributes to the sensitization of cough pathways at the peripheral and/or central level via neuroplasticity and it manifests most often as augmented coughing. Cardiorespiratory coupling is an important mechanism responsible for a match between oxygenation and cardiac output and bidirectional relationships exist between respiration and cardiovascular function.
View Article and Find Full Text PDFCost-impact analysis of baroreflex activation therapy in chronic heart failure patients in the United States.
BMC Cardiovasc Disord
March 2021
Medical University of South Carolina, Charleston, SC, USA.
Background: The study evaluated the cost of baroreflex activation therapy plus guideline directed therapy (BAT + GDT) compared to GDT alone for HF patients with reduced ejection fraction and New York Heart Association Class III or II (with a recent history of III). Baroreflex activation therapy (BAT) is delivered by an implantable device that stimulates the baroreceptors through an electrode attached to the outside of the carotid artery, which rebalances the autonomic nervous system to regain cardiovascular (CV) homeostasis. The BeAT-HF trial evaluated the safety and effectiveness of BAT.
View Article and Find Full Text PDFBaroreflex gain and time of pressure decay at different body temperatures in the tegu lizard, Salvator merianae.
PLoS One
January 2021
Department of Physiological Sciences, Federal University of São Carlos, São Carlos, São Paulo, Brazil.
Ectotherms may experience large body temperature (Tb) variations. Higher Tb have been reported to increase baroreflex sensitivity in ectotherm tetrapods. At lower Tb, pulse interval (PI) increases and diastolic pressure decays for longer, possibly resulting in lower end-diastolic pressures and mean arterial pressures (Pm).
View Article and Find Full Text PDFPotential role of intermittent functioning of baroreflexes in the etiology of hypertension in spontaneously hypertensive rats.
JCI Insight
October 2020
Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan, USA.
The spontaneously hypertensive rat (SHR) is a genetic model of primary hypertension with an etiology that includes sympathetic overdrive. To elucidate the neurogenic mechanisms underlying the pathophysiology of this model, we analyzed the dynamic baroreflex response to spontaneous fluctuations in arterial pressure in conscious SHRs, as well as in the Wistar-Kyoto (WKY), the Dahl salt-sensitive, the Dahl salt-resistant, and the Sprague-Dawley rat. Observations revealed the existence of long intermittent periods (lasting up to several minutes) of engagement and disengagement of baroreflex control of heart rate.
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