Immobilised N-methyl ammonium ions have been used to simultaneously select, amplify and isolate a pseudo-peptide receptor from a dynamic library of hydrazones.
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http://dx.doi.org/10.1039/b201465c | DOI Listing |
Eur J Med Chem
May 2022
Department of Pharmaceutical Chemistry, College of Pharmacy, Jouf University, Sakaka, Aljouf, 2014, Saudi Arabia. Electronic address:
Ghrelin is a multifunctional gastrointestinal acylated peptide, primarily synthesized in the stomach and regulates the secretion of growth hormone and energy homeostasis. It plays a central role in modulating the diverse biological, physiological and pathological functions in vertebrates. The synthesis of ghrelin receptor ligands after the finding of growth hormone secretagogue developed from Met-enkephalin led to reveal the endogenous ligand ghrelin and the receptors.
View Article and Find Full Text PDFChem Commun (Camb)
June 2016
Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
This paper reports the binding properties of tetrameric pseudo-peptide receptors for protonated cytidines. The receptors, which were isolated from a dynamic combinatorial chemistry (DCC) experiment, bind the analytes with affinities that depend on the presence or absence of excess acid, and with a stoichiometry that is both concentration and temperature dependent.
View Article and Find Full Text PDFJ Pineal Res
November 2009
Department of Chest Medicine, Chi-Mei Medical Center, Yong Kang City, Taiwan.
Low levels of melatonin in circulation had been reported to be related to the development of diabetes. Melatonin administration in animals increases hepatic glycogen content to lower blood glucose. However, the signaling pathway for these effects is still unclear.
View Article and Find Full Text PDFChem Commun (Camb)
August 2007
Farmacognosia, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Rosario, Argentina.
Two different macrocyclic members of a pseudo-peptide hydrazone dynamic combinatorial library were amplified using the diastereomeric templates quinine and quinidine.
View Article and Find Full Text PDFJ Comb Chem
May 2007
Laboratoire des Aminoacides, Peptides et Protéines (LAPP), UMR 5810, Faculté de Pharmacie, Université de Montpellier I et II, 15 avenue Charles Flahault, 34060 Montpellier, France.
Alpha melanocyte stimulating hormone (alpha-MSH) is a widely distributed hormone. This tridecapeptide exhibits various biological activities mediated through different receptors. alpha-MSH binds to the melanocortin-1 receptor (MC1-R), mainly expressed in keratinocytes and melanocytes, inducing melanogenesis and anti-inflammatory processes.
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