Two charged aminoxyls, ammonium (1-oxyl-2,5,5-trimethylpyrrolidin-2-yl)methanesulfonate and ammonium 2-methyl-2-[(N-(4-tert-butylphenyl)oxyl]propanesulfonate, obtained by methods easily adaptable to the preparation of various other aminoxyls are totally soluble in water but are partially associated in other solvents.
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http://dx.doi.org/10.1039/b110766f | DOI Listing |
Int J Biol Macromol
December 2021
P.G. Demidov Yaroslavl State University, Yaroslavl 150000, Russian Federation.
The binding of aminoxyls to polymers extends their potential use as antioxidants and EPR-reporting groups and opens up new horizons for tailoring new smart materials. In this work, we synthesized and characterized non-sulfated and N-sulfated water-soluble amphiphilic chitosans with a critical micelle concentration of 0.02-0.
View Article and Find Full Text PDFFolia Morphol (Warsz)
May 2003
Department of Anatomy and Neurobiology, Medical University of Gdańsk, Poland.
In the present study we have shown that quinolinic aromatic aminoxyls are very efficient in protecting lipids of endoplasmic reticulum membranes against hydroperoxide-induced oxidation. The efficacy of these aminoxyls as protectors of lipids was much higher than the water-soluble 4-OH-TEMPO. We have also shown that QAL causes distinct changes of the morphology of mitochondria: from filamentous to granular enlarged structure via the folding of the former.
View Article and Find Full Text PDFChem Commun (Camb)
March 2002
Ecole Normale Supérieure and CNRS, 24 Rue Lhomond, F75231 Paris, France.
Two charged aminoxyls, ammonium (1-oxyl-2,5,5-trimethylpyrrolidin-2-yl)methanesulfonate and ammonium 2-methyl-2-[(N-(4-tert-butylphenyl)oxyl]propanesulfonate, obtained by methods easily adaptable to the preparation of various other aminoxyls are totally soluble in water but are partially associated in other solvents.
View Article and Find Full Text PDFFree Radic Biol Med
May 1995
Academy of Physical Education, Department of Bioenergetics, Gdansk, Poland.
A study on peroxyl radical induced oxidation of rat liver microsomal membranes in the presence of different indolinic and quinolinic aminoxyls (Scheme 1) was carried out in order to test their efficiency as antioxidants in lipid and protein peroxidation. The extent of lipid peroxidation was quantified by the amount of malondialdehyde (MDA) produced, and the measurement of carbonyl residues was used as an index of microsomal protein oxidation. The results obtained suggest that lipid soluble indolinic and quinolinic aminoxyls are efficient in protecting lipids and proteins of biological membranes against oxidation.
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