Pretreatment of mice with a subcutaneous (s.c.) injection of LiCl (1, 3, 10 mmol/kg) 18 h prior to testing produced dose-related attenuation of the reciprocal hindlimb scratching (RHS) response induced by intrathecal (i.t.) administration of pilocarpine. LiCl (10 mmol/kg, 424 mg/kg) pretreatment shifted the pilocarpine (2 microg)-induced RHS dose-response curve about 5-fold to the right compared to vehicle-injected controls (ED(50) = 2.97 and 0.56 microg, respectively). Coadministration of inositol-1,4,5-trisphosphate (IP(3); 5, 10, 20 microg), but not inositol hexaphosphate (0.03-3 microg), myo-inositol (10 microg) or EDTA (1.33 microg), produced dose-related reversal of the LiCl effect. IP(3) administration alone neither produced RHS nor enhanced the pilocarpine-induced RHS in animals not pretreated with LiCl. These findings provide in vivo evidence for a possible link between RHS and a LiCl-sensitive, possibly phosphoinositide-related, effector pathway.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1159/000064346 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Voluntary co-contraction of ankle muscles alters motor unit discharge characteristics and reduces estimates of persistent inward currents.
J Physiol
September 2024
Department of Physical Therapy and Human Movement Sciences, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
Motoneuronal persistent inward currents (PICs) are facilitated by neuromodulatory inputs but are highly sensitive to local inhibitory circuits. Estimates of PICs are reduced by group Ia reciprocal inhibition, and increased with the diffuse actions of neuromodulators released during remote muscle contraction. However, it remains unknown how motoneurons function in the presence of simultaneous excitatory and inhibitory commands.
View Article and Find Full Text PDFReciprocal Inhibition and Coactivation of Ankle Muscles in Low- and High-Velocity Forward and Backward Perturbations.
J Mot Behav
October 2024
Graduate Program in Health Technology, Pontifícia Universidade Católica do Paraná, Curitiba, Brazil.
Reciprocal inhibition and coactivation are strategies of the central nervous system used to perform various daily tasks. In automatic postural responses (APR), coactivation is widely investigated in the ankle joint muscles, however reciprocal inhibition, although clear in manipulative motor actions, has not been investigated in the context of APRs. The aim was to identify whether reciprocal inhibition can be observed as a strategy in the recruitment of gastrocnemius Medialis (GM), Soleus (So) and Tibialis Anterior (TA) muscles in low- and high-velocity forward and backward perturbations.
View Article and Find Full Text PDFInterlimb transfer of sequential motor learning between upper and lower effectors.
Gait Posture
September 2024
Universite Claude Bernard Lyon 1, LIBM, Inter-university Laboratory of Human Movement Sciences, UR 7424, F-69622 Villeurbanne, France.
Background: Interlimb transfer of sequential motor learning (SML) refers to the positive influence of prior experiences in performing the same sequential movements using different effectors. Despite evidence from intermanual SML, and while most daily living activities involve interlimb cooperation and coordination between the four limbs, nothing is known about bilateral SML transfer between the upper and lower limbs.
Research Question: We examined the transfer of bilateral SML from the upper to the lower limbs and vice versa.
The mechanism of static postural control in the impact of lower limb muscle strength asymmetry on gait performance in the elderly.
PeerJ
July 2024
School of Physical Education, Shanghai University of Sport, Shanghai, China.
Background: Abnormal gait is prevalent among the elderly population, leading to reduced physical activity, increased risk of falls, and the potential development of dementia and disabilities, thus degrading the quality of life in later years. Numerous studies have highlighted the crucial roles of lower limb muscle strength asymmetry and static postural control in gait, and the reciprocal influence of lower limb muscle strength asymmetry on static postural control. However, research exploring the interrelationship between lower limb muscle strength asymmetry, static postural control, and gait performance has been limited.
View Article and Find Full Text PDFContemporary utilization of three-column osteotomy techniques in a prospective complex spinal deformity multicenter database: implications on full-body alignment and perioperative course.
Spine Deform
November 2024
Department of Orthopaedic Surgery, Duke University Medical Center, 2301 Erwin Road, Durham, NC, 27710, USA.
Article Synopsis
- The study investigates the effectiveness of three-column osteotomies (3CO) in correcting complex sagittal spinal deformities and their associated complications during surgery for adult spinal deformity (ASD).
- It included a cohort of 648 patients, comparing outcomes between those who underwent 3CO and those who did not, finding that 3CO procedures had a significantly higher incidence of complications but offered similar health-related quality of life (HRQL) benefits.
- Results indicated that patients undergoing 3CO were older and frailer, faced more severe deformities, and experienced higher risks for blood loss and longer hospital stays, but they achieved greater segmental correction outcomes.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!