The Salmonella enterica serovar Typhimurium znuABC genes encoding a high-affinity zinc uptake system and its regulatory zur gene have been cloned. Salmonella serovar Typhimurium zur and znuC knockout mutants have been constructed by marker exchange. The 50% lethal dose of the znuC mutant increased when either orally or intraperitoneally inoculated in BALB/c mice, while virulence of the zur mutant decreased only when mice were intraperitoneally challenged.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC128140 | PMC |
| http://dx.doi.org/10.1128/IAI.70.8.4721-4725.2002 | DOI Listing |
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