Substitution of 7-OH by small hydrophobic groups on zanamivir resulted in the retaining of low nanomolar inhibitory activities against not only influenza A virus sialidase but also influenza A virus in cell culture. These compounds were prepared by treatment of the corresponding 7-substituted sialic acids derived from 4-modified N-acetyl-D-mannosamine (ManNAc) using enzyme-catalyzed aldol condensation.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/s0960-894x(02)00328-1 | DOI Listing |
Publication Analysis
Top Keywords
influenza virus
8
synthesis anti-influenza
4
anti-influenza virus
4
virus activity
4
activity 4-guanidino-7-substituted
4
4-guanidino-7-substituted neu5ac2en
4
neu5ac2en derivatives
4
derivatives substitution
4
substitution 7-oh
4
7-oh small
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!