A case of lichen planus-lupus erythematosus overlap syndrome with eyelid involvement.

Purpose: To report a case of lichen planus-lupus erythematosus overlap syndrome with eyelid involvement. Lichen planus and lupus erythematosus infrequently coexist in the same patients. Ocular involvement has rarely been reported for both diseases.

Case Report: We describe a case of lichen planus-lupus erythematosus overlap syndrome with eyelid involvement. Histopathologic and immunofluorescent studies were done on buccal, lip, left conjunctival, malar, auricular and scalp lesions. The immunopathologic features of the conjunctiva, buccal mucosa and lip were consistent with lichen planus, while those of the malar, auricular and scalp lesions favoured lupus erythematosus.

Results: The patient was successfully treated with hydroxychloroquine 200 mg/day and all lesions responded to therapy within weeks.

Conclusions: This is a rare example of two coexisting autoimmune disease entities: lichen planus of the oral mucosa, lip, eyelid and discoid lupus erythematosus of the skin. To our knowledge, this is the first reported case of lichen planus-lupus erythematosus overlap syndrome with eyelid involvement.