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Impact of and Extracts on UVA-Irradiated on 3D Cultured Melanoma Cells: A Proteomic Insight.
Cells
November 2024
Department of Analytical Chemistry, Medical University of Bialystok, Mickiewicza 2D, 15-222 Bialystok, Poland.
Melanoma is one of the most malignant forms of skin cancer, characterised by the highest mortality rate among affected patients. This study aims to analyse and compare the effects of lipid extracts from the microalgae () and () on the intra and extracellular proteome of UVA-irradiated melanoma cells using a three-dimensional model. Proteomic analysis revealed that UVA radiation significantly increases the levels of pro-inflammatory proteins in melanoma cells.
View Article and Find Full Text PDFMyocardial deposition of aluminum, arsenic, cadmium, and lead accelerates heart failure and alters UPRmt in humans.
Toxicology
December 2024
Department of Pathophysiology, University of Zagreb School of Medicine, Croatia. Electronic address:
In the myocardium of control subjects and patients undergoing heart transplantation or left ventricular assist device implantation (LVAD), we analyzed concentrations of Al, As, Cd, Pb, and Ni using inductively coupled plasma mass spectrometry. Myocardial generation of oxidative-stress-induced lipid peroxidation was analyzed by quantifying concentration of 4-Hydroxynonenal (4-HNE) with ELISA and pro-apoptotic DAPK2 gene expression was determined with quantitative RT-PCR. Compared to six control hearts, myocardial samples of 128 individuals undergoing heart transplantation or LVAD implantation exhibited a moderate increase in deposition of five tested non-essential elements, which was significantly increased only for Cd and cumulative deposition of Al, As, Cd, and Pb.
View Article and Find Full Text PDFExtracellular vesicles released by ALL patients contain HNE-adducted proteins: Implications of collateral damage.
Free Radic Biol Med
December 2024
Department of Toxicology and Cancer Biology, University of Kentucky, USA; Markey Cancer Center, University of Kentucky, USA. Electronic address:
Off-target neuronal injury is a serious side-effect observed in cancer survivors. It has previously been shown that pediatric acute lymphoblastic leukemia (ALL) survivors have a decline in neurocognition compared to healthy age-matched counterparts. Elevated oxidative stress has been documented to be a mediator in off-target tissue damage in cancer survivors.
View Article and Find Full Text PDFOral administration of silicon-based agents attenuates renal fibrosis.
Biochem Biophys Res Commun
January 2025
Department of Urology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka Suita, Osaka, 565-0871, Japan.
Article Synopsis
- Renal fibrosis worsens with oxidative stress during renal failure, and this study investigates whether silicon-based agents can help combat fibrosis in a mouse model.
- Mice treated with silicon showed a significant reduction in renal fibrosis, tubular cell death, and harmful protein expressions by day 14 after surgery compared to untreated groups.
- RNA sequencing indicated that silicon treatment downregulated pathways related to tissue fibrosis and reduced levels of pro-fibrotic factors and oxidative stress in the renal tissues.
Organophosphate flame retardants associated with increased oxidative stress biomarkers and elevated FeNO levels in general population of children: The Hokkaido study.
Sci Total Environ
December 2024
Faculty of Health Sciences, Hokkaido University, 060-0812 Sapporo, Japan; Center for Environmental and Health Sciences, Hokkaido University, 060-0812 Sapporo, Japan. Electronic address:
Our previous study found that exposure to higher organophosphate flame retardants (PFRs) was associated with increased prevalence of wheeze and type 2 inflammation among school-aged children. It remains unclear whether PFR exposure elevates oxidative stress in these general pediatric population, thereby potentially contributing to the development of allergic diseases. This study examined the associations between individual and mixture exposure to PFRs and oxidative stress in children aged 9-12 years (n = 423).
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