AI Article Synopsis
- Coal tar preparations used in dermatology contain polycyclic aromatic hydrocarbons, which are linked to cancer in animals, and increase the excretion of 1-hydroxypyrene in patients with atopic dermatitis.
- The study found that the amount of coal tar applied and the body area affected significantly influenced the 1-hydroxypyrene levels, while factors like dermatitis severity and skin barrier condition had less impact.
- Due to the potential cancer risk from coal tar, careful use in dermatological treatments is advised, but more research and risk assessments are needed to understand the effects of short-term high exposure.
Article Abstract
Coal tar preparations, as used in dermatological practice, contain numerous polycyclic aromatic hydrocarbons of which many are proven animal carcinogens. Increased urinary 1-hydroxypyrene excretion in patients with atopic dermatitis treated with topical coal tar preparations has been demonstrated. Little is known about the relationship between the dermal uptake of polycyclic aromatic hydrocarbons on the one hand and the amount of tar applied to the skin, the total body area affected, the condition of the epidermal barrier and the severity of the dermatitis on the other. We compared urinary 1-hydroxypyrene excretion rate with these variables. The urinary 1-hydroxypyrene excretion rate was highly dependent on the total amount of tar applied to the skin and the total body area affected, and less on the severity of the atopic dermatitis or the condition of the epidermal barrier. Exposure to therapeutic doses of coal tar leads to much higher rates of urinary 1-hydroxypyrene excretion than occupational exposure. Because of the potential carcinogenicity of coal tar, as clearly demonstrated both in animal studies and from occupational exposure, careful consideration should be given to the use of coal tar preparations in dermatological practice. However, the risk of short-term high exposure is unknown. Restriction of the use of coal tar should be based on epidemiological studies and/or appropriate risk models taking into account its relative safety established over many years of clinical use.
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| http://dx.doi.org/10.1007/s00403-002-0311-5 | DOI Listing |
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