Accumulation of tributyltin (TBT) in serum, liver, muscle, and gill of olive flounder (Paralichthys olivaceus) was examined in a 30-d static-renewal exposure. Tributyltin accumulated rapidly in the serum of the olive flounder and to a greater extent than in the other tissues. The accumulated TBT concentrations in tissues were in the order of serum > gill > liver > muscle on a dry-weight basis. Tributyltin also was detected in the serum of feral fine-spotted flounder, Pleuronichthys cornutus, collected from the coastal area. The mean TBT concentration in serum (2,470 ng Sn/g) of the fine-spotted flounder was about 40 times higher than that in the liver (60 ng Sn/g) and 200 times higher than that in the muscle (27 ng Sn/g) on a dry-weight basis. The TBT concentrations in serum and sediment demonstrated a positive correlation. The percent TBT composition to total butyltin was much higher in the serum (71%) than in the other tissues and sediment (<47%). These results suggest that the analysis of fish blood serum could be a useful tool for monitoring exposure to TBT in the marine environment.
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Article Synopsis
- * Exposed embryos showed significant delays in hatching, malformations, reduced locomotion, and decreased feeding activity, indicating that TBT affects physiological functions even at low concentrations.
- * This research also reveals for the first time the presence of tin in various tissues of TBT-treated hatchlings, emphasizing the need for further investigations into the cellular and molecular mechanisms of TBT's harmful effects.
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