AI Article Synopsis
- The calcium entry blocker dilceren (nimodipine) was tested on rats and cats to observe its effects on blood circulation.
- Overall, dilceren generally increased local and regional blood flow in healthy animals, but there were instances where circulation was reduced or stable, leading to low blood pressure.
- After global brain ischemia, dilceren consistently enhanced cerebral blood flow in all tests conducted.
Article Abstract
The influence of the calcium entry blocker dilceren (nimodipine) on the local and regional circulation was studied in rats and cats. In the majority of experiments on intact animals, dilceren increased the local and regional blood flow. However, in some cases, the circulation decreased or remained unchanged, which was accompanied by pronounced hypotension. Administered after global brain ischemia, dilceren improved the cerebral hemodynamics in all experiments.
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[Comparative study of dilceren (nimodipine) on the cerebral circulation in the intact animals and animals subjected to ischemic brain damage].
Eksp Klin Farmakol
August 2002
Laboratory of Pharmacology of Cerebrovascular Disorders, Institute of Pharmacology, Russian Academy of Medical Sciences, Baltiiskaya ul. 8, Moscow, 125315 Russia.
Article Synopsis
- The calcium entry blocker dilceren (nimodipine) was tested on rats and cats to observe its effects on blood circulation.
- Overall, dilceren generally increased local and regional blood flow in healthy animals, but there were instances where circulation was reduced or stable, leading to low blood pressure.
- After global brain ischemia, dilceren consistently enhanced cerebral blood flow in all tests conducted.
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