Cardinal pathological mechanisms responsible for initiation and development of the Raynaud's phenomenon have been presented according to the current data from literature. The role of endothelin-1, cytokins and growth factor in pathophysiology of this phenomenon have been highlighted. According to own observations randomised results of investigation in these patients have shown that basic disease stimulate the development of the vasomotoric disturbances: idiopathic Raynaud's phenomenon and Raynaud's phenomenon which accompany connective tissue disease.
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