AI Article Synopsis
- The study examined the relationship between the thyroid and thymus glands in white Wistar rats, particularly under conditions of iodine deficiency.
- In chronic iodine deficiency, the thymus underwent more significant shrinkage, with juvenile rats experiencing a 25% reduction in thymic tissue compared to 11% in healthy controls.
- The overall mass of the thymus remained stable due to an increase in connective tissue, indicating that iodine deficiency disrupts the normal function and regulation of the immune system.
Article Abstract
The experiment on white Wistar rats provided morphometric and morphofunctional evidence on correlations between the thyroid and thymus in health and thyroid transformation in iodine deficiency. In chronic iodine deficiency the rate and volume of thymic physiological involution increase. Total shrinkage of the parenchyma of cortical and core substances of thymic lobules from juvenile animals reaches 25% in the experimental group vs 11% in the reference group. The absolute mass of the organ was stable due to increased volume of connective tissue of the interlobular septa and intralobular perivascular spaces. Iodine-dependent thyroid transformation brings about profound changes in correlations between tissue components and cellular subpopulations of the thymic lobule indicating disturbed mechanisms of immunological regulation in iodine deficiency.
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