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Novel concepts and improvisation for treating postpartum haemorrhage: a narrative review of emerging techniques.
Reprod Health
August 2023
Department of Obstetrics and Gynaecology, University of Botswana, Notwane Rd, Gaborone, Botswana.
Background: Most treatments for postpartum haemorrhage (PPH) lack evidence of effectiveness. New innovations are ubiquitous but have not been synthesized for ready access.
Narrative Review: Pubmed 2020 to 2021 was searched on 'postpartum haemorrhage treatment', and novel reports among 755 citations were catalogued.
Sequential targeting dual-responsive magnetic nanoparticle for improved therapy of lung metastatic breast cancer.
J Drug Target
July 2023
Department of Medicinal Chemistry, School of Pharmacy, Chongqing Medical University, Chongqing, PR China.
Lung metastatic breast cancer is a leading cause of cancer-related death in women and difficult to treat due to non-specific drug delivery. Herein a sequential targeting dual-responsive magnetic nanoparticle was fabricated, where FeO nanoparticle was used as magnetic core, then sequentially coated with tetraethyl orthosilicate, bis[3-(triethoxy-silyl)propyl] tetrasulfide, and 3-(trimethoxysilyl) propylmethacrylate to afford -C = C- on the surface for further polymerisation with acrylic acid, acryloyl-6-ethylenediamine-6-deoxy-β-cyclodextrin using N, N-bisacryloylcy- stamine as cross-linker, obtaining pH/redox dual-responsive magnetic nanoparticle (MNPs-CD) to delivery doxorubicin (DOX) for suppressing lung metastatic breast cancer. Our results suggested DOX-loaded nanoparticle could target the lung metastases site by sequential targeting, in which they first be delivered to the lung and even the metastatic nodules through size-driven, electrical interaction, and magnetic field-guided mechanisms, then be effectively internalised into the cancer cells followed by intelligently triggering DOX release.
View Article and Find Full Text PDFA systematic review of treatment options for post-prostatectomy incontinence.
World J Urol
November 2022
Guy's Hospital, King's College London, London, UK.
Purpose: Urinary incontinence remains common in men after prostatectomy. Current guidance suggests early corrective surgery to those that are still incontinent after trying Pelvic Floor Muscle Therapy, however, other treatments are now available. This review aims to evaluate all currently available treatment options for men with post-prostatectomy incontinence (PPI).
View Article and Find Full Text PDF[Intraoperative transesophageal echocardiography as monitoring procedure in noncardiac surgery patients].
Anaesthesist
December 2021
Klinik für Anästhesiologie und Operative Intensivmedizin, Universitätsklinikum Augsburg, Augsburg, Deutschland.
Transesophageal echocardiography (TEE) is firmly established in cardiac surgery for diagnostics, hemodynamic monitoring and as a guiding tool. Dynamic and (patho)physiological processes of the heart can be immediately depicted. Ideally, therapeutic changes can be derived.
View Article and Find Full Text PDFExtracorporeal Blood Purification in Moderate and Severe COVID-19 Patients: A Prospective Cohort Study.
Blood Purif
March 2022
Zan Mitrev Clinic, Skopje, North Macedonia.
Introduction: Coronavirus disease 2019 (COVID-19) is characterized by hyperinflammation and coagulopathy. Severe cases often develop respiratory distress, requiring mechanical ventilation and with critical cases progressing to acute respiratory distress syndrome. Control of hyperinflammation has been proposed as a possible therapeutic avenue for COVID-19; extracorporeal blood purification (EBP) modalities offer an attractive mean to ameliorate maladaptive inflammation.
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