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Simulation of fluid flow with Cuprophan and AN69ST membranes in the dialyzer during hemodialysis.
Biomed Phys Eng Express
January 2025
Ingeniería y Tecnología, Universidad Nacional Autonoma de Mexico Facultad de Estudios Superiores Cuautitlan, Av. 1o de Mayo S/N, Santa María las Torres, Campo Uno, 54740 Cuautitlán Izcalli, Edo. de Méx., Cuautitlan Izcalli, Estado de México, 54740, MEXICO.
Hemodialysis is a crucial procedure for removing toxins and waste from the body when kidneys fail to perform this function effectively. This study addresses the need to improve the efficiency and biocompatibility of membranes used in dialyzers. We simulate fluid flow through two types of membranes, Cuprophan (cellulosic) and AN69ST (synthetic), to understand the complex mechanisms involved and quantify key variables such as pressure, concentration, and flow.
View Article and Find Full Text PDFContribution of Adsorption and Hematocrit Levels to Ganciclovir Clearance in an in Vitro Continuous Hemodiafiltration Model.
Biol Pharm Bull
July 2024
Graduate School of Pharmaceutical Sciences, Chiba University.
Article Synopsis
- The study examines how diafiltration, adsorption, and hematocrit levels affect the clearance of ganciclovir (GCV) during continuous hemodiafiltration (CHDF) using various membrane types.
- Results indicate that diafiltration is the primary factor influencing GCV clearance, while adsorption has minimal impact.
- Hematocrit levels do not significantly alter the clearance relationship between plasma and blood GCV concentrations, suggesting that clearance can be estimated from effluent flow rates.
Severe disseminated infection by hypermucoviscous Klebsiella pneumoniae successfully treated by intensive therapy with continuous hemodiafiltration using AN69ST: A case report and review of the literature.
J Infect Chemother
November 2023
Division of Nephrology and Rheumatology, Department of Internal Medicine, Faculty of Medicine, Fukuoka University, Fukuoka, Japan.
Klebsiella pneumoniae (Kpn) is one of the most common gram-negative bacilli causing lung, urinary tract, and biliary tract infections. However, as a distinct entity from classic Kpn, hypervirulent Kpn causing liver abscess, endophthalmitis, and lung abscess with poor prognoses has been reported mainly in East and Southeast Asia since the mid-1980s. Although the definition of hypervirulent Kpn is unclear, the hypermucoviscosity of Kpn is considered an important feature of hypervirulence.
View Article and Find Full Text PDFIn vitro analysis of factors affecting the continuous hemodiafiltration clearance of teicoplanin.
Artif Organs
April 2023
Division of Pharmacy, Chiba University Hospital, Chiba, Japan.
Background: In the treatment of sepsis, continuous hemodiafiltration (CHDF) and the administration of antibiotics such as teicoplanin (TEIC) are frequently performed in parallel. We aimed to clarify the factors influencing the CHDF clearance (CL ) of TEIC using a polymethylmethacrylate (PMMA) membrane or a polyacrylonitrile and sodium methallyl sulfonate copolymer membrane coated with polyethylenimine (AN69ST). We also investigated whether the adsorption of TEIC onto the hemofilters inhibits the adsorption of interleukin (IL)-6 onto the membranes.
View Article and Find Full Text PDFMembrane adsorption in vancomycin treatment is membrane type dependent in CVVHDF: dose correction is crucial.
Crit Care
April 2022
ICU Department, Centre Hospitalier Universitaire Brugmann-Brugmann University Hospital, Place Van Gehuchtenplein, 4, 1020, Brussels, Belgium.
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