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Acupuncture alleviates neuro-inflammatory injury in rats with cognitive impairment induced by Parkinson's disease based on cGAS-STING signaling pathway.
Zhen Ci Yan Jiu
February 2025
Department of Encephalopathy.
Objectives: To observe the effect of acupuncture on neuro-inflammation in rats with cognitive impairment induced by Parkinson's disease (PD) based on the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) signaling pathway.
Methods: SD rats were randomly grouped into sham operation, model, acupuncture, acupuncture+empty and acupuncture+cGAS over-expression groups, with 12 rats in each group. The PD model was established by injecting 6-hydroxydopamine (6-OHDA, 8 μg/rat) into the substantia nigra pars compacta of the left midbrain (AP:-5.
Isolation, identification, and potentiality of gut-derived probiotic bacteria from , stinging catfish.
J Adv Vet Anim Res
September 2024
Department of Fisheries Technology, Faculty of Fisheries, Bangladesh Agricultural University, Mymensingh, Bangladesh.
Article Synopsis
- The study aimed to extract and identify probiotic bacteria from wild stinging catfish in Bangladesh using traditional and molecular techniques.
- Researchers collected catfish from natural sites, cultured bacteria from their guts, and tested 10 selected isolates for their probiotic potential through various pH and bile tolerance tests.
- Five specific bacterial isolates showed strong probiotic characteristics, indicating they could enhance aquaculture production for stinging catfish.
Case Report: Multidisciplinary management of a patient with indolent systemic mastocytosis and refractory symptoms.
Front Allergy
October 2024
Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United States.
Systemic mastocytosis (SM) is a rare hematologic condition characterized by the proliferation and accumulation in tissue of clonal mast cells in multiple organ systems. The release of mast cell mediators in the indolent disease type and the predominant mast cell infiltration of tissues in advanced disease contribute to the heterogeneous clinical presentation. The disease driver in >90% of adult cases is an activating mutation, with D816V being the most frequent.
View Article and Find Full Text PDFDisrupting endogenous retroelements with a reverse transcriptase inhibitor alleviates DSS-induced colitis in mice.
Mucosal Immunol
October 2023
College of Animal Science and Technology ＆ College of Veterinary Medicine, Zhejiang A＆F University, Key Laboratory of Applied Technology on Green-Eco-Healthy Animal Husbandry of Zhejiang Province, Provincial Engineering Research Center for Animal Health Diagnostics ＆ Advanced Technology, Zhejiang International Science and Technology Cooperation Base for Veterinary Medicine and Health Management, China Australia Joint Laboratory for Animal Health Big Data Analytics, Hangzhou, Zhejiang 311300, China. Electronic address:
Endogenous retroelements play vital roles in sustaining immune homeostasis. Activation of endogenous retroelements can trigger cGAS/STING pathway and downstream pro-inflammatory cytokine production. M1 macrophages, which can be induced by pro-inflammatory cytokines, are involved in the development of colitis.
View Article and Find Full Text PDFControl of innate immunity and lipid biosynthesis in neurodegeneration.
Front Mol Neurosci
July 2024
Department of Neurology, University of Utah, Salt Lake City, UT, United States.
The cGAS-STING innate immunity pathway and the SREBP-activated cholesterol and fatty acid synthesis pathway are abnormally co-regulated in neurodegenerative disease. Activation of STING signaling occurs at the endoplasmic reticulum (ER) membrane with STING anchored by INSIG1 along with SREBP and the sterol-bound SREBP cleavage activating protein (SCAP) when sterols are in abundance. When sterols are low, the INSIG-dependent STING pathway is inactivated and the SREBP-SCAP complex is translocated to the Golgi where SREBP is cleaved and translocated to the nucleus to transactivate genes for cholesterol and fatty acid synthesis.
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