[Basic results of the investigation of the effects of antiorthostatic hypokinesia on the functioning of various systems in monkey's organism].

Presented are results of comprehensive studies of functioning various body systems of Macaca mulatta after 4 weeks in antiorthostatic hypokinesia (head-down tilting, HDT). HDT deteriorated monkeys' tolerance of +Gz, altered the higher nervous functioning, and brought about serious disorders in coordination and locomotion. It also impacted energy metabolism, reduced hydration of organism, caused various shifts in the neuroendocrine system, circulation and its controls, and protein, carbohydrate and mineral metabolism. HDT resulted in inhibition of the lymphoid activity of structural components of the lymph nodes, changes in the musculoskeletal apparatus of the lower limbs, atrophic developments in the iliac crest spongiosis, and reduction of the oxidative potential of fibers in the crus extensors, and the number of capillaries in a fiber. These observations are ascribed to redistribution of the body fluids, hypokinesia per se and absence of the effects of support. This HDT model can be applied to monkeys for studying processes of the hypokinetic syndrome and developing countermeasures.