Ubiquinone and ubichromenol content was studied at different levels of organism supply with vitamin E. The content of these substances in the albino rat liver with vitamin E-deficiency is shown to decrease by 16 and 23%, respectively. The intravenous administration of alpha-tocopherol to the vitamin E-deficiency rats causes a gradual 45% increase in the ubiquinone content 4h after which remains at the same level for 8 h; the ubichromenol content 2 h latter is 1.7 times as high and then it lowers gradually up to the level in the avitaminous animals.
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Novel approach over template molecule elimination in molecularly imprinted polymers by using heat activated persulfate.
J Chromatogr A
April 2024
Departamento de Química, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Junín 956, Buenos Aires C1113AAD, Argentina; Consejo Nacional de Investigaciones Científicas y Tecnológicas, CONICET, Buenos Aires, Argentina.
Article Synopsis
- This study introduces a method for effectively removing template molecules from molecularly imprinted polymers using heat-activated persulfate, addressing issues with incomplete template removal seen in current techniques.
- The research utilized a polymer designed for Coenzyme Q extraction to test this new approach, ensuring that the heat treatment accurately eliminated the template without compromising the polymer's performance.
- Results showed that this method is efficient and eco-friendly, providing comparable selectivity for target analytes to traditional methods, marking a significant improvement in trace analysis applications.
The paper is dedicated to the study of peculiarities of ubiquinone and ubichromenol distribution and metabolism in subcellular fractions of rats' liver under A,E-hypovitaminosis. It is shown, that dietary deprivation of vitamins A and E leads to a sharp decrease in intensity of CoQ biosynthesis in rats' liver tissue and to its intracellular redistribution. Under these circumstances the observed decrease in the inclusion of labelled tyrosine in rats' liver CoQ under A,E-hypovitaminosis may be really caused by dietary deprivation of vitamin E.
View Article and Find Full Text PDFSome peculiarities of ubiquinone (Q) biosynthesis in the livers of vitamin E-deficient rats induced in vitro by alpha-tocopherol and S-adenosylmethionine (SAM) were investigated. When [C3H3]SAM was used as a precursor, alpha-tocopherol added to the sample induced a marked elevation of the content of Q concomitantly with a drastic increase (2.82-fold) of specific radioactivity of Q in the liver as compared to control.
View Article and Find Full Text PDFThe effect of mixtures of phospholipids (PL) and natural antioxidants (AO)--tocopherol (TP), ubiquinone, ubichromenol, vitamin K, on the value of induction periods and on the rate of initiated oxidation of model substrates (++methyl oleate, mixtures of fatty acid methyl ethers, ethylbenzene) was studied at 60 degrees C. The possibility of synergism of different AO in the presence of PL has been established. It has been shown that the action of bioantioxidants in lipids may be increased 2.
View Article and Find Full Text PDFUsing chemiluminescence method, the oxidation level of lipids extracted from various organs and tissues of fish Coregonus peled (Gmelin) was investigated. The analysis of interrelation between the oxidation level, quantity and composition of phospholipids (PL), fatty acids (FA), natural antioxidants (NAO) was carried out. The oxidation level of the lipids under investigation is shown to increase in series: first go internal fat lipids, then--lipids of brain, white muscles, immature eggs, red muscles, liver.
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