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Calcium sensing receptor expression is downregulated in gastroenteropancreatic neuroendocrine tumours via epigenetic mechanisms.
Int J Cancer
March 2025
OCDEM, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
Article Synopsis
- Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) can be either hormone-secreting or non-secreting, have serious health implications, and an average survival of 75-124 months.
- Research shows that key genes involved in the tumor's development, especially epigenetic regulators like MEN1, DAXX, and ATRX, are often mutated, but their effects are not well understood.
- The calcium sensing receptor (CaSR) is significantly reduced in GEP-NETs, potentially due to DNA methylation and chromatin modifications, suggesting it functions as a tumor suppressor by inhibiting cell growth in pancreatic NETs.
Management of functional neuroendocrine tumors.
Curr Probl Cancer
October 2024
ENETS Center of Excellence, Division of Endocrinology and Metabolism, University of Iowa, 200 Hawkins Drive, Room E400 GH, Iowa City, Iowa, 52242, USA. Electronic address:
Article Synopsis
- * Managing the symptoms associated with functional NENs may require approaches like tumor removal, chemotherapy, or specialized therapies aimed at reducing hormone production and its effects on the body.
- * This review emphasizes the importance of addressing the hormonal symptoms of NENs alongside traditional tumor reduction strategies to enhance the overall wellbeing of patients.
Expression profiles of cadherin 17 and claudin 18.2 in comparison with peptide hormonal expression in pancreatic neuroendocrine tumours: Implications for targeted immunotherapy.
Pathol Res Pract
October 2024
Department of Health and Medical Sciences, Shinshu University Graduate School of Medicine, Matsumoto, Japan; Department of Medical Sciences, Shinshu University Graduate School of Medicine, Science and Technology, Matsumoto, Japan. Electronic address:
Cadherin 17 (CDH17) and claudin 18.2 (CLDN18.2) are highly selective markers of intestinal and gastric lineages and are expressed in adenocarcinomas of various organs.
View Article and Find Full Text PDFPancreatic masses in children: a single-center experience over two decades.
Eur J Pediatr
October 2024
Division of Pediatric General Surgery, Stanford University, Palo Alto, CA, USA.
Unlabelled: Pancreatic masses are extremely rare in pediatric patients, with limited data available. This lack of data makes the diagnosis and management of these tumors in children extremely challenging. Therefore, we aimed to describe the presentations, clinical course, and outcomes of children with pancreatic tumors at our center.
View Article and Find Full Text PDFCharacteristics, therapy, and outcome of rare functioning pancreatic neuroendocrine neoplasms.
Sci Rep
August 2024
Department of Visceral, Thoracic and Vascular Surgery, University Hospital Marburg, Philipps University Marburg, Marburg, Germany.
Article Synopsis
- * Out of 216 patients with pNENs treated from 2002 to 2022, 12 were identified as rf-pNENs, including different subtypes like vasoactive intestinal polypeptide, glucagon, and calcitonin-producing tumours.
- * Following surgery, most patients showed positive outcomes, with a median follow-up of 75 months indicating that those who had complete resections (R0) and no liver metastases had a better prognosis, with six patients remaining alive and disease-free.
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