François Leroy de la Faudignére was the founder of the family. Although he was not an expert in dentistry, he acquired a good reputation of dentist in the second half of the 18th century. He published some books between 1766 and 1780. He lived in Paris and set up in 1780 at the Pavillon Royal, Plave Royale no1 (Place des Vosges nowadays). He was mainly busy with selling an approved analgesic elixir of his own. Out of his 5 children, 2 have been experts in dentistry and one of his daughters, Marie Marianne Françoise, married Jacques René Duval, Maître en Chirurgie. François died six weeks after his daughter's marriage but her brothers sued her about the elixir their father had bequeathed to her. She won her case and carried on selling the elixir with Duval. Her daughter married Jean Nicolas Marjolin, a famous surgeon. Their son René Nicolas became a surgeon too.

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