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Comparison of postoperative oxygenation in children receiving sugammadex versus neostigmine for reversal of neuromuscular blockade: a retrospective cohort study.
Can J Anaesth
January 2025
Outcomes Research Consortium, Houston, TX, USA.
Purpose: Residual neuromuscular blockade can impair postoperative respiratory mechanics, promoting hypoxemia and pulmonary complications. Sugammadex, with its unique mechanism of action, may offer a more effective reversal of neuromuscular blockade and respiratory function than neostigmine. We sought to test the primary hypothesis that children undergoing noncardiac surgery exhibit better initial recovery oxygenation when administered sugammadex than those administered neostigmine.
View Article and Find Full Text PDFNanoscale Ligand Spacing Regulates Mechanical Force-Induced Cancer Cell Killing.
Nano Lett
January 2025
Department of Bioengineering, Indian Institute of Science, Bangalore 560012, India.
Cancer cells sense and respond to the extracellular environment, with differences in nanoscale ligand spacing affecting their behavior. Emerging reports show that stretch/ultrasound-mediated mechanical forces promote apoptosis (mechanoptosis) by increasing myosin contractility. Since myosin contractility is critical for nanoscale-ligand spacing-regulated cell behavior, we study the effect of ligand spacing on mechanoptosis.
View Article and Find Full Text PDFThe synergistic effect of 1-butyl-3-methylimidazolium chloride and glycerol on the performance of chitosan films.
Int J Biol Macromol
January 2025
College of Material Science and Engineering, Northeast Forestry University, Harbin 150040, PR China. Electronic address:
In this study, we examined the plasticizing effects of 1-butyl-3-Methylimidazolium Chloride (BmimCl), glycerol, and their combination on chitosan (CS) films. Additionally, we examined the effect of plasticizers for chitosan films structure and physicochemical properties of CS films by FTIR, XRD, SEM and mechanism of action of plasticizers on the structure of CS films. The results indicated that the interaction between BmimCl and chitosan is mainly ionic interaction and hydrogen bonding, while the interaction between glycerol and CS is mainly hydrogen bonding.
View Article and Find Full Text PDFMechanical properties, degradation action, and biocompatibility of in situ nanoparticle-reinforced MgZn/Zn composite prepared via roll bonding.
Acta Biomater
January 2025
Centre for Additive Manufacturing, School of Engineering, RMIT University, Melbourne, Victoria 3001, Australia. Electronic address:
Zinc (Zn)-based alloys and composites are anticipated to emerge as a category of degradable metallic biomaterials with exceptional prospects for bone-implant applications owing to their superior biocompatibility and biofunctionality. Unfortunately, the limited strength of Zn alloys in their as-cast state restricts their use in clinical applications. In this study, we started with pure magnesium (Mg) powders and Zn sheets, and successfully fabricated MgZn/Zn composites using accumulative roll bonding (ARB).
View Article and Find Full Text PDFDithiocarbamate-Based Sequence-Defined Oligomers as Promising Membrane-Disrupting Antibacterial Agents: Design, Activity, and Mechanism.
ACS Appl Bio Mater
January 2025
Department of Chemistry, Indian Institute of Technology Palakkad, Palakkad, Kerala 678623, India.
The emerging prevalence of antimicrobial resistance demands cutting-edge therapeutic agents to treat bacterial infections. We present a synthetic strategy to construct sequence-defined oligomers (SDOs) by using dithiocarbamate (DTC). The antibacterial activity of the synthesized library of SDOs was studied using a Gram-positive and a Gram-negative .
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