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Serum fatty acid profiles in systemic lupus erythematosus and patient reported outcomes: The Michigan Lupus Epidemiology & Surveillance (MILES) Program.
Front Immunol
January 2025
University of Michigan, Department of Internal Medicine, Ann Arbor, MI, United States.
Introduction: Despite progress in systemic lupus erythematosus (SLE) treatment, challenges persist in medication adherence due to side effects and costs. Precision nutrition, particularly adjusting fatty acid intake, offers a cost-effective strategy for enhancing SLE management. Prior research, including our own, indicates that increased consumption of omega-3 polyunsaturated fatty acids (PUFAs) correlates with improved outcomes in SLE patients.
View Article and Find Full Text PDFCD36-mediated uptake of oxidized LDL induces double-negative regulatory T cell ferroptosis in metabolic dysfunction-associated steatotic liver disease.
Metabolism
December 2024
Medical Research Center, Beijing Institute of Respiratory Medicine and Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China; Department of Gastroenterology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China; Immunology Research Center for Oral and Systemic Health, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China. Electronic address:
Background: Metabolic alterations have been shown to instigate liver inflammation in metabolic dysfunction-associated steatotic liver disease (MASLD), but the underlying mechanism is not fully elucidated. During MASLD progression, intrahepatic CD3TCRαβCD4CD8 double negative T regulatory cells (DNT) decrease cell survival and immunosuppressive function, leading to aggravated liver inflammation. In this study, we aim to reveal the underlying mechanisms that cause changes in DNT during MASLD progression.
View Article and Find Full Text PDFFibronectin type III domain containing protein 5/irisin alleviated sepsis-induced acute kidney injury by abating ferroptosis through the adenosine 5'-monophosphate-activated protein kinase/nuclear factor erythroid-2-related factor 2 signaling pathway.
Cytojournal
November 2024
Department of Emergency, The First People's Hospital of Tongxiang, Tongxiang, Zhejiang, China.
Objective: Ferroptosis has been described in association with acute kidney injury (AKI)-induced sepsis. Fibronectin type III domain containing protein 5 (FNDC5)/irisin plays a crucial role in renal protection. The objective of this study was to investigate whether FNDC5/irisin is involved in AKI-induced sepsis by modulating ferroptosis, and the molecular mechanisms that may be involved.
View Article and Find Full Text PDFAccumulation of lipophilic and proteinophilic halogenated organic pollutants (HOPs) in the different types of feathers of laying hens.
J Hazard Mater
December 2024
State Key Laboratory of Organic Geochemistry and Guangdong Provincial Key Laboratory of Environmental Protection and Resources Utilization, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou 510640, China; Guangdong-Hong Kong-Macao Joint Laboratory for Environmental Pollution and Control, Guangzhou 510640, China; CAS Center for Excellence in Deep Earth Science, Guangzhou 510640, China.
This study investigated the bioaccumulation of halogenated organic pollutants (HOPs) in three types of feathers from laying hens through exposure experiments. The HOPs included lipophilic polychlorinated biphenyls (PCBs) and polybrominated diphenyl ethers (PBDEs), as well as proteinophilic perfluoroalkyl carboxylic acids (PFCAs). Concentrations of PCBs, PBDEs, and short-chain PFCAs (≤8) were significantly higher in the body feathers than in the primary feathers, while long-chain PFCAs (>8) showed no significant differences among primary, tail, and body feathers.
View Article and Find Full Text PDF[Study on the mechanism of moxibustion regulating ferroptosis-lipid metabolism pathway to improve synovitis inflammatory injury in rheumatoid arthritis rats].
Zhen Ci Yan Jiu
December 2024
School of Acupuncture-moxibustion and Tuina, Anhui University of Chinese Medicine, Hefei 230038, China.
Article Synopsis
- The study aimed to investigate how moxibustion can alleviate inflammation in rheumatoid arthritis (RA) by influencing ferroptosis and lipid metabolism.
- Researchers used 48 rats divided into four groups (normal, model, moxibustion, and moxibustion with an ACSL4 inhibitor) to assess moxibustion's effects over 15 days using various biochemical and histological techniques.
- Results showed that moxibustion significantly improved antioxidant levels and reduced inflammatory markers in the rats, indicating its potential as a treatment for RA-related synovitis.
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