Paragonimiasis is a zoonosis caused by adult trematodes of the Paragonimus genus. The infection in humans is a result of a complex transmission cycle that includes two obligate intermediate hosts, a snail and a crustacean or a crayfish, and a definitive mammalian host. It has been shown that 9 of the more than 40 species of Paragonimus described affect humans in over 39 countries in Asia, Africa and America. It is estimated that 20.7 million people have paragonimiasis and it is calculated that 195 million people are at risk of being infected. The illness usually is caused once the parasite has settled in the lung at the site of the main clinical symptoms: cough, thoracic pain and hemoptysis. The diagnosis of paragonimiasis is based on the patient's history, the parasitological findings (ova in sputum and in feces), and the result of radiological and immunological tests. In severe cases, the patient may suffer from life-threatening hemoptysis or pneumothorax. Currently, praziquantel is the drug of choice.
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Considerable genetic diversity within Paragonimus heterotremus in Luang Prabang, northern Lao People's Democratic Republic.
Infect Genet Evol
January 2025
Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand; Mekong Health Science Research Institute, Khon Kaen University, Khon Kaen 40002, Thailand. Electronic address:
Paragonimiasis, caused by infection with lung flukes of the genus Paragonimus, remains a significant public health concern in Southeast Asia. In Lao People's Democratic Republic (Lao PDR), information on the distribution and genetic diversity of Paragonimus species is limited. This study investigated Paragonimus metacercariae in freshwater (mountain) crabs and analyzed their genetic diversity and phylogenetic relationships.
View Article and Find Full Text PDFGlobal, regional and national disease burden of food-borne trematodiases: projections to 2030 based on the Global Burden of Disease Study 2021.
Infect Dis Poverty
December 2024
National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases,National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention (Chinese Center for Tropical Diseases Research), NHC Key Laboratory of Parasite and Vector Biology, WHO Collaborating Center for Tropical Diseases, Shanghai, People's Republic of China.
Background: Food-borne trematodiases (FBTs), mainly encompassing clonorchiasis, fascioliasis, fasciolopsiasis, opisthorchiasis, and paragonimiasis, is a neglected public health problem, particularly in the WHO South-East Asia and the Western Pacific regions. This study evaluates the global, regional, and national disease burden of FBTs from 1990 to 2021 and projects trends to 2030, underscore the need for targeted prevention and control.
Methods: Using the Global Burden of Disease 2021 database, the crude and the age-standardized prevalence rate (ASPR) and age-standardized prevalence disability-adjusted life years rate (ASDR) of FBTs at the global, regional and national level from 1990 to 2021 were described.
Gray foxes (Urocyon cinereoargenteus) as natural definitive hosts of Paragonimus mexicanus.
Vet Parasitol Reg Stud Reports
November 2024
Laboratory of Helminthology, Faculty of Microbiology, University of Costa Rica, San José, Costa Rica; Centro de Investigación en Enfermedades Tropicales, University of Costa Rica, San José, Costa Rica. Electronic address:
Paragonimus mexicanus is a trematode that causes pulmonary and extrapulmonary infections in humans, characterized by chest pain, dyspnea, fever, and weight loss. The detection of Paragonimus spp. is primarily achieved through the microscopic observation of eggs in feces, sputum, and pleural fluid.
View Article and Find Full Text PDFNuclear ribosomal transcription units in Asian Paragonimus species (Paragonimidae: Platyhelminthes): genetic characteristics, polymorphism, and implications for intersuperfamilial phylogeny.
Parasitol Res
November 2024
Immunology Department, Institute of Biotechnology (IBT), Vietnam Academy of Science and Technology (VAST), 18. Hoang Quoc Viet Rd, Cau Giay, Hanoi, Vietnam.
The entire transcribed sequences (from the 5' terminus of 18S to the 3' terminus of 28S rRNA genes) of the ribosomal transcription units (rTU*) of five Asian Paragonimus species were obtained and characterized. The rTU* length was 7661 bp for P. heterotremus (LC strain, Vietnam), 7422 bp for P.
View Article and Find Full Text PDFStudy on the prevalence of trematode cercariae infection in freshwater snails in Manipur, India.
J Parasit Dis
December 2024
Department of Microbiology, Sikkim Manipal Institute of Medical Sciences, Sikkim Manipal University (SMU), Tadong, Gangtok, 737102 India.
Article Synopsis
- In a study analyzing 4,074 snails, researchers found that 1.05% were infected with different trematode cercariae, with specific species of snails showing varying rates of infection.
- Statistical analysis indicated no significant link between the geographical location of the snails and the occurrence of cercarial infection, shedding light on how these snails contribute to the transmission of paragonimiasis.
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