Trimethyl tin chloride (TMTC) is a highly toxic organotin compound that affects four main target organs: the brain, liver, immune system and skin. Exposure can occur by inhalation, ingestion or direct skin absorption. Trimethyl tin is but one of many hazardous substances with potentially serious health consequences to which individuals working in research laboratories may be exposed. We report a preventable case of TMTC exposure. Better understanding of the Canadian Workplace Hazardous Materials Information System (WHMIS) legislation and its applicability to the research laboratory situation would prevent such unnecessary exposure to hazardous substances.
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http://dx.doi.org/10.1093/occmed/52.4.227 | DOI Listing |
J Liposome Res
November 2024
Department of Pharmaceutical Sciences, School of Health Sciences and Technology, UPES, Dehradun, India.
This work aimed to formulate surface-modified berberine hydrochloride (BER)-loaded liposomes containing nasal gel for bran targeting. The liposomes were prepared by ethanol-injection method and optimized following a 3 full-factorial design. Size, morphology, zeta potential, permeation, and release were estimated.
View Article and Find Full Text PDFPoult Sci
January 2025
Animal Science Faculty of Technology, Northeast Agricultural University, Harbin 150030, PR China. Electronic address:
Trimethyl tin (TMT) is a good stabilizer for plastic products but is also a toxic environmental pollutant. Selenium has good antioxidant and anti-inflammatory properties and has been widely used in the poultry industry. However, it has not been reported whether selenium enrichment can antagonize TMT-induced viral hepatitis in poultry.
View Article and Find Full Text PDFNanomaterials (Basel)
July 2024
Semiconductor Technology and System, Imec, Kapeldreef 75, B-3001 Leuven, Belgium.
Chemistry
July 2024
Chair of Inorganic and Structural Chemistry, Bielefeld University, Universitätsstraße 25, 33615, Bielefeld.
Chalice-shaped tridentate poly-Lewis acids (PLA) based on the tribenzotriquinacene (TBTQ) scaffold have been synthesised. Stannylation of the alkyne units, attached via phenyl-spacers to the benzhydrylic positions to the TBTQ scaffold, with MeNSnMe afforded the trimethyltin substituted TBTQ derivative. Replacement of these tin functions with other elements resulted in rigid boron- and aluminium-functionalised PLAs.
View Article and Find Full Text PDFAAPS PharmSciTech
February 2024
Department of Pharmaceutics, Bharati Vidyapeeth (Deemed to be University), Poona College of Pharmacy, Paud Road, Erandwane, Pune, 411038, India.
Quercetin (QT) shows potential for protecting against neurodegenerative diseases like Alzheimer's. However, its limited bioavailability and instability in physiological pH hinder its clinical use. The purpose of this work is to construct QT-filled nanostructured lipid carriers (QT-NLC) intranasal in situ gel to enhance pharmacokinetic and pharmacodynamic performance.
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