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Characterization of Microcapsules Obtained from Lemon Balm Extract (Melissa officinalis L.) by the Ionic Gelation Process.
Plant Foods Hum Nutr
January 2025
Post Graduate Program in Food Science and Technology, Federal University of Sergipe, Av. Marcelo Deda Chagas, s/n, Jardim Rosa Elze, São Cristóvão, 49100-000, SE, Brazil.
The plant specie, lemon balm (Melissa officinalis L.) is one of the most important species of the Lamiaceae family and its use as a plant extract has been highlighted by the population and the scientific community due to its rich chemical composition and the presence of bioactive compounds with potential antioxidant activity, associated with various health benefits. Research and development of innovative technologies are focused on the identification of these substances, their properties and applications.
View Article and Find Full Text PDFComparative Analysis of Recurrent Neural Networks with Conjoint Fingerprints for Skin Corrosion Prediction.
J Chem Inf Model
January 2025
Division of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen 40002, Thailand.
Skin corrosion assessment is an essential toxicity end point that addresses safety concerns for topical dosage forms and cosmetic products. Previously, skin corrosion assessments required animal testing; however, differences in skin architecture and ethical concerns regarding animal models have fostered the advancement of alternative methods such as and models. This study aimed to develop deep learning (DL) models based on recurrent neural networks (RNNs) for classifying skin corrosion of chemical compounds based on chemical language notation, molecular substructure, physicochemical properties, and a combination of these three properties called conjoint fingerprints.
View Article and Find Full Text PDFUsing the AP1 Transcription Factor FOSL1 to Assess the Exacerbation of Psoriasis.
Curr Mol Med
January 2025
Laboratory of Physicochemical and Genetic Problems in Dermatology, Center of Theoretical Problems in Physico-Chemical Pharmacology at Russian Academy of Sciences, Moscow Russia.
Background: The transcription factor AP1 plays a crucial role in the proliferation, apoptosis, and terminal differentiation of epidermal keratinocytes.
Objective: This study aimed to clarify whether the subunit of AP1, FOSL1 protein, can be used to assess the exacerbation of psoriasis by evaluating its changes in protein and mRNA levels in cultured epidermal keratinocytes and skin specimens of the patients prescribed with bathwater PUVA (Psoralen and UVA) therapy. This study aimed to investigate FOSL1, a subunit of the transcription factor AP-1, as a potential biomarker for psoriasis by examining its protein and mRNA expression in skin specimens from patients undergoing bathwater PUVA (Psoralen and UVA) therapy and cultured epidermal keratinocytes.
Comparative analysis of solvent-based and solvent-free (melting) methods for fabricating 3D-printed polycaprolactone-hydroxyapatite composite bone scaffolds: physicochemical/mechanical analyses and cytocompatibility.
Front Bioeng Biotechnol
January 2025
Division of Surgery and Interventional Science, University College London, Royal Free Hospital Campus, London, United Kingdom.
Purpose: The study conducts a comparative analysis between two prominent methods for fabricating composites for bone scaffolds-the (solid) solvent method and the solvent-free (melting) method. While previous research has explored these methods individually, this study provides a direct comparison of their outcomes in terms of physicochemical properties, cytocompatibility, and mechanical strength. We also analyse their workflow and scalability potentials.
View Article and Find Full Text PDFStatus analysis of quality control of administered infusion solution with cytotoxic drugs.
Oncol Rev
January 2025
Department of Pharmacy, Tianjin First Central Hospital, Nankai University, Tianjin, China.
The administered infusion solution is a sterile preparation that can be used directly for intravenous infusion in patients by mixing one or more intravenous drugs using aseptic operation technology. The pharmacy intravenous admixture service (PIVAS) center is a professional technical service department in hospitals, where the majority of inpatient-administered infusion solutions are prepared. During the processes of dissolution, dilution, preparation, storage, and use of intravenous drugs, the quality control of the administered infusion solution can be affected by various factors.
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