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The potential dangers of whooping cough: a case of rib fracture and pneumothorax.
BMC Infect Dis
November 2024
Department of Pharmacology, Third Faculty of Medicine, Charles University, Ruská 87, Prague, 100 00, Czech Republic.
Background: Pertussis, also known as whooping cough, is an acute respiratory illness primarily caused by Bordetella pertussis. Highly contagious, it poses significant morbidity and mortality risks, especially in infants. Despite widespread vaccination efforts, pertussis cases have recently resurged globally.
View Article and Find Full Text PDFBPP0974 is a Bordetella parapertussis adhesin expressed in the avirulent phase, implicated in biofilm formation and intracellular survival.
Microb Pathog
August 2024
CINDEFI (UNLP, CONICET La Plata), Facultad de Ciencias Exactas, Universidad Nacional de La Plata, La Plata, Argentina. Electronic address:
B. parapertussis is a bacterium that causes whooping cough, a severe respiratory infection disease, that has shown an increased incidence in the population. Upon transmission through aerosol droplets, the initial steps of host colonization critically depend on the bacterial adhesins.
View Article and Find Full Text PDFThe Chaperonin TRiC/CCT Inhibitor HSF1A Protects Cells from Intoxication with Pertussis Toxin.
Toxins (Basel)
January 2024
Institute of Experimental and Clinical Pharmacology, Toxicology and Pharmacology of Natural Products, Ulm University Medical Center, 89081 Ulm, Germany.
Pertussis toxin (PT) is a bacterial AB-toxin produced by and a major molecular determinant of pertussis, also known as whooping cough, a highly contagious respiratory disease. In this study, we investigate the protective effects of the chaperonin TRiC/CCT inhibitor, HSF1A, against PT-induced cell intoxication. TRiC/CCT is a chaperonin complex that facilitates the correct folding of proteins, preventing misfolding and aggregation, and maintaining cellular protein homeostasis.
View Article and Find Full Text PDFGenomic evidence and virulence properties decipher the extra-host origin of Bordetella bronchiseptica.
J Appl Microbiol
September 2023
Department of Biotechnology, Institute of Life Sciences, Nalco Square, Bhubaneswar-751023, India.
Until recently, members of the classical Bordetella species comprised only pathogenic bacteria that were thought to live exclusively in warm-blooded animals. The close phylogenetic relationship of Bordetella with Achromobacter and Alcaligenes, which include primarily environmental bacteria, suggests that the ancestral Bordetellae were probably free-living. Eventually, the Bordetella species evolved to infect and live within warm-blooded animals.
View Article and Find Full Text PDFGenomic epidemiology and multilevel genome typing of .
Emerg Microbes Infect
December 2023
School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, Australia.
causes pertussis (or whooping cough), a severe respiratory infectious disease in infants, although it can be prevented by whole cell and acellular vaccines. The recent pertussis resurgence in industrialised countries is partly attributed to pathogen adaptation to vaccines, while emergence of antimicrobial resistance, specifically to macrolides in China, has become a concern. Surveillance of current circulating and emerging strains is therefore vital to understand the risks they pose to public health.
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