A simple and rapid procedure was developed for purification of cyclotron produced 86Y via the 86Sr(p,n) 86Y reaction. A commercially available Sr(II) selective resin was used to separate 86Y from the cyclotron irradiated Sr(II) target with a recovery of the enriched Sr(II) target while yielding a 75-80% recovery of 86Y suitable for radiolabeling either proteins or peptides. To demonstrate the utility of this methodology, the anti-HER2 monoclonal antibody Herceptin was radiolabeled with the purified 86Y and compared to 111In labeled Herceptin. The biodistribution study demonstrated that 111In-Herceptin, while a suitable surrogate for 90Y in the major organs, did not parallel the uptake of 86Y-Herceptin in the bone, and thus may not accurately predict the level of 90Y accumulation in the bone for clinical RIT applications. This result exemplifies the requirement of employing appropriate matched pair isotopes for imaging and therapy to insure that dosimetry considerations may be addressed accurately.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/s0969-8051(02)00322-0 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Selective Adsorption of Sr(II) from Aqueous Solution by NaFePOCO: Experimental and DFT Studies.
Molecules
June 2024
College of Nuclear Science and Technology, Naval University of Engineering, Wuhan 430033, China.
The efficient segregation of radioactive nuclides from low-level radioactive liquid waste (LLRW) is paramount for nuclear emergency protocols and waste minimization. Here, we synthesized NaFePOCO (NFPC) via a one-pot hydrothermal method and applied it for the first time to the selective separation of Sr from simulated LLRW. Static adsorption experimental results indicated that the distribution coefficient remained above 5000 mL·g, even when the concentration of interfering ions was more than 40 times that of Sr.
View Article and Find Full Text PDFEnhanced adsorption dynamics and thermal stability of radioactive Sr(II) by lamellar Nb-doped sodium vanadosilicate via self-assembly and conditional natroxalate intercalation.
J Hazard Mater
June 2024
State Key Laboratory of Featured Metal Materials and Life-cycle Safety for Composite Structures, School of Resources, Environment and Materials, Guangxi University, Nanning 530004, PR China. Electronic address:
To promote the environmentally friendly and sustainable development of nuclear energy, it is imperative to address the treatment of wastewater generated by the nuclear industry. This necessitates the enhancement of fission product reclamation efficiency post-treatment. This study aims to combine defect control and confined self-assembly strategies for the precise design of interlayer spacing (14.
View Article and Find Full Text PDFMolten salt synthesis of MXene-derived hierarchical titanate for effective strontium removal.
J Hazard Mater
May 2024
Laboratory of Nuclear Energy Chemistry, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China. Electronic address:
The removal and recovery of radioactive Sr(II) from wastewater and seawater has been of great concern due to the negative environmental impacts of nuclear energy development and the potential risk of nuclear accidents. Herein, a facile molten salt synthesis strategy was developed to systematically investigated the reaction of different types of MXenes with nitrates. Among the products, K intercalated hierarchical titanate nanostructures (K-HTNs) obtained from the direct chemical transformation of multilayered TiCT exhibited unique layered structures, good physicochemical properties, and outstanding adsorption performance for Sr(II).
View Article and Find Full Text PDFPhosphination of amino-modified mesoporous silica for the selective separation of strontium.
J Hazard Mater
April 2024
School of Nuclear Science and Technology, University of South China, Hengyang 421001, PR China. Electronic address:
Radioactive strontium (Sr) is considered as one of the most dangerous radionuclides due to its high biochemical toxicity. For the efficient and selective separation of Sr from acidic environments, a novel functional adsorbent CEPA@SBA-15-APTES was prepared in this work through the phosphorylation of amino-modified mesoporous silica with organic content of approximately 20 wt%. CEPA@SBA-15-APTES was characterized by TEM, SEM, EDS, TG-DSC, BET, FTIR, and XPS techniques, revealing its characteristics of an ordered hexagonal lattice-like structure and rich functional groups.
View Article and Find Full Text PDFStudy on Dynamic Column Behavior and Complexation Mechanism of DBS-Modified Crown Ether-Based Silica to Sr.
Toxics
November 2023
School of Nuclear Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240, China.
A crown ether-loaded hybrid adsorbent suitable for the separation and enrichment of strontium from high-level liquid waste was synthesized. 4',4'(5″)-di(tert-butylcyclohexano)-18-crown-6 (DtBuCH18C6) and its modifiers dodecyl benzenesulfonic acid (DBS) and 1-dodecanol were impregnated into silica-based polymer support. The hybrid adsorbent exhibited excellent Sr(II) selectivity ability, and effective chromatographic separation and recovery of Sr(II) from simulated high-level liquid waste could be achieved with a (DtBuCH18C6 + DBS + dodec)/SiO-P packed column.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!