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Factors associated with willingness to perform expedited excisional treatment for patients at high risk for cervical precancer.
Gynecol Oncol Rep
February 2025
H. Lee Moffitt Cancer Center & Research Institute, Health Outcomes and Behavior, Tampa, FL, United States.
Background: The 2019 ASCCP Risk-Based Management Consensus Guidelines prefer expedited treatment, defined as proceeding to excisional treatment without first performing colposcopic biopsy, for patients with screening results indicating a high risk of cervical precancer. In this mixed methods study, we explored clinician attitudes toward expedited treatment.
Methods: In 2021, a national sample of 671 clinicians who performed colposcopy completed surveys; a subset (n = 41) of clinicians who performed colposcopy and/or directed patient treatment completed qualitative interviews.
[Management of patients in cardiac arrest in the emergency department].
Lakartidningen
January 2025
överläkare, akutkliniken, Skånes universitetssjukhus Lund.
Cardiac arrest is the most time-sensitive condition that personnel face in the emergency department. Optimal management consists of good quality cardiopulmonary resuscitation, the simultaneous performance of focused investigations to identify potential reversible causes, and the delivery of cause-specific treatments. In order to manage patients with cardiac arrest in an efficient manner, team members need to have clearly defined roles and ready access to required equipment.
View Article and Find Full Text PDFQuantitative proteomic analysis unveils a critical role of VARS1 in hepatocellular carcinoma aggressiveness through the modulation of MAGI1 expression.
Mol Cancer
January 2025
Department of Cell Biology, Physiology, and Immunology, University of Córdoba, CIBER Pathophysiology of Obesity and Nutrition (CIBERobn), Córdoba, 14004, Spain.
Background: Hepatocellular carcinoma (HCC) genetic/transcriptomic signatures have been widely described. However, its proteomic characterization is incomplete. We performed non-targeted quantitative proteomics of HCC samples and explored its clinical, functional, and molecular consequences.
View Article and Find Full Text PDFA study to identify individuals at risk to be affected by late-onset Pompe disease who had previously been given a non-specific or tentative diagnosis for their muscle weakness (Pompe PURSUE).
Orphanet J Rare Dis
January 2025
Department of Human Genetics, Emory University, Atlanta, GA, USA.
Background: Late-onset Pompe disease (LOPD) is an autosomal recessive lysosomal storage disorder that results in severe progressive proximal muscle weakness. Over time, reductions in muscle strength result in respiratory failure and a loss of ambulation. Delayed diagnosis of LOPD deprives patients of treatments that can enhance quality of life and potentially slow disease progression.
View Article and Find Full Text PDFCommunicating neurological prognosis in the prenatal period: a narrative review and practice guidelines.
Pediatr Res
January 2025
Division of Neurology, Department of Pediatrics, Duke University School of Medicine, Durham, NC, USA.
Clinicians may face an array of challenges in conducting fetal neurological consultations including prognostic uncertainty, a lack of training in fetal counseling, and limited opportunity to build rapport with families. In this setting, it is critical to employ high-quality, family-centered care to allow expectant parents to make informed decisions. Despite the challenges and gravity of these consultations, there remains limited data outlining best conduct and communication practices.
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