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Large library docking of tangible molecules has revealed potent ligands across many targets. While make-on-demand libraries now exceed 75 billion enumerated molecules, their synthetic routes are dominated by a few reaction types, reducing diversity and inevitably leaving many interesting bioactive-like chemotypes unexplored. Here, we investigate the large-scale enumeration and targeted docking of isoquinuclidines.
View Article and Find Full Text PDFTraumatic internal carotid artery aneurysm distant from facial bone fractures treated with a flow diverter stent: A case report.
Acute Med Surg
January 2025
Department of Emergency and Critical Care Medicine Institute of Medicine, University of Tsukuba Hospital Tsukuba Ibaraki Japan.
Background: Traumatic intracranial aneurysms (TICAs) can be fatal if ruptured. We report a case of a TICA, distant from facial bone fractures, successfully treated with flow diverter (FD) before rupture.
Case Presentation: A 20-year-old woman was admitted following a car accident.
Criminal Offending and Incarceration in United States Adults With Early Phase Psychosis and Comorbid Substance Use Disorder.
Early Interv Psychiatry
February 2025
Department of Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Aim: Studies have shown that people experiencing early phase psychosis (EPP) are at increased risk for criminal conviction and incarceration. However, there is limited data looking at overall legal burden. To address these gaps in the literature, the goal of this study was to categorise criminal charges and convictions using the United States Federal Bureau of Investigation (FBI) uniform crime reporting (UCR) program, assess frequency of incarcerations, and describe the frequency of substance use disorder (SUD) diagnoses and its relationship to criminal offending and incarceration in a well categorised EPP population.
View Article and Find Full Text PDFBody composition of older adults with normal body mass index. Cross-sectional analysis of the Toulouse Frailty clinic.
J Frailty Aging
February 2025
IHU HealthAge, Frailty Clinic, Toulouse University Hospital, Gérontopôle, La Cité de la Santé, Hôpital La Grave, Place Lange, Toulouse 31059, France. Electronic address:
Background: Body mass index (BMI) determines general corpulence and health, whatever age, sex or clinical background. Normal BMI (18.5-24.
View Article and Find Full Text PDFRamadan fasting and glycemic control in patients with type 2 diabetes: A real-world data analysis.
Prim Care Diabetes
January 2025
Department of Epidemiology and Preventive Medicine, School of Public Health, Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel; Levinsky-Wingate Academic College, Campus Wingate, Netanya 4290200, Israel. Electronic address:
Objectives: The aim of this study is to assess the impact of Ramadan intermittent fasting on glycemic control in individuals diagnosed with type 2 diabetes.
Methods: This historical prospective study utilized electronic health records from a major state-mandated healthcare provider. The research sample included Muslim adults aged 40-70 years, who had been diagnosed with type 2 diabetes.
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