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Discovery of potent anti-toxoplasmosis drugs from secondary metabolites in Citrus limon (lemon) leaves, supported in-silico study.
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Department of Zoonotic Diseases, National Research Centre, Dokki, Giza, 12622, Egypt.
Toxoplasmosis induced by Toxoplasma gondii is a well-known health threat, that prompts fatal encephalitis increased with immunocompromised patients, in addition, it can cause chorioretinitis, microcephaly, stillbirth in the fetus and even led to death. Standard therapy uses sulfadiazine and pyrimethamine drugs revealed beneficial results during the acute stage, however, it has severe side effects. UPLC-ESI-MS/MS used to explore C.
View Article and Find Full Text PDFUtilizing Artificial neural networks (ANN) to regulate Smart cities for sustainable Urban Development and Safeguarding Citizen rights.
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Department of Architecture, Rafsanjan Branch, Islamic Azad University, Rafsanjan, Iran.
The advent of smart cities has brought about a paradigm shift in urban management and citizen engagement. By leveraging technological advancements, cities are now able to collect and analyze extensive data to optimize service delivery, allocate resources efficiently, and enhance the overall well-being of residents. However, as cities become increasingly interconnected and data-dependent, concerns related to data privacy and security, as well as citizen participation and representation, have surfaced.
View Article and Find Full Text PDFPotential backfiring effects of Marine Protected Areas on kelp herbivory.
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MARE-Marine and Environmental Sciences Centre & ARNET-Aquatic Research Network Associated Laboratory - CETEMARES, Av. do Porto de Pesca 30, Peniche, 2520-620, Portugal.
The management and creation of Marine Protected Areas (MPAs) is currently under great focus, with international organisations aiming to protect 30% of our oceans by 2030. The success of MPAs depends on a nuanced understanding of local ecological dynamics and threats, which can significantly influence ecosystem balance. Herbivory can be a stressor for foundation species, namely kelp forests, contributing to their decline in several regions of the globe.
View Article and Find Full Text PDFIdentifying the facilitators of Iran's alcoholic beverage black market and presenting solutions for harm reduction: a qualitative document analysis.
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Department of Health Policy and Management, School of Management and Medical Informatics, Tabriz University of Medical Sciences, Tabriz, Iran.
Background: Despite Iran's prohibition politics regarding alcoholic beverages consumption, marketing, and trading, there is a flourishing black market. Often, alcohol producers on this black market do not adhere alcohol production standards, resulting in a lot of deaths and significant consequences each year. Accordingly, this study was carried out to identify facilitators for the growth of the black market for alcoholic beverages in Iran and provide solutions for harm reduction.
View Article and Find Full Text PDFThe laws of medical malpractice have historically differed in significant ways from general liability laws. Until the mid-twentieth century, physician liability in the United States was limited to cases in which the doctor and patient had an established professional relationship. In the 1970s, courts and legislatures began carving out exceptions when patients posed an imminent threat to identifiable third parties.
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